文章摘要
高盐饮食对盐敏感性高血压大鼠肾脏损伤的影响
Effects of high salt diet on kidney injury ofrats with salt-sensitive hypertension
投稿时间：2020-02-12  
DOI：10.3969/j.issn.1000-0399.2020.08.002
中文关键词: 盐敏感性高血压  炎症  白介素-6  白介素-1β  肿瘤坏死因子-α  肾脏
英文关键词: Salt-sensitive hypertension  Inflammation  Interleukin 6  Interleukin 1β  Tumor necrosis factor α  Kidney
基金项目:陕西省自然科学基础研究计划（项目编号：S2017-ZRJJ-MS-2212）
作者单位E-mail
任洁 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室  
胡经文 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室  
郭统帅 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室  
何明俊 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室  
刘富强 710068 西安 陕西省人民医院心内科  
牟建军 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室 mujjun@163.com 
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中文摘要:
      目的 研究高盐饮食对盐敏感性高血压大鼠肾脏组织损伤的影响。方法 将20只实验大鼠按照大鼠品系分为对照组（SS-13BN大鼠，n=10）与盐敏感性高血压大鼠模型组（Dahl/SS大鼠，n=10），通过喂食盐含量为8%的高盐饲料构建盐敏感性高血压大鼠模型，分析两组大鼠肾脏组织损伤程度及肾脏组织中白介素-6（IL-6）、白介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）的表达情况。结果 模型组大鼠的收缩压为（183.82±3.87）mmHg，对照组为（129.03±3.94）mmHg，差异有统计学意义（P<0.05）。模型组大鼠肾脏组织中Nephrinuria含量为（12.12±0.92）mg/d、肾损伤程度评分为（1.93±0.52）分、TNF-α含量为（623.14±43.12）pg/mg，均高于对照组，差异有统计学意义（P<0.05）。模型组大鼠肾脏组织中IL-6 mRNA的相对表达量为（2.25±0.81）、IL-1β mRNA为（2.89±0.86），均高于对照组，差异有统计学意义（P<0.05）。模型组大鼠肾脏组织中IL-6蛋白相对表达量为（1.71±0.08）、IL-1β为（2.23±0.13），均高于对照组，差异有统计学意义（P<0.05）。结论 高盐摄取会对盐敏感大鼠的肾脏造成严重的损伤，引起炎症反应，从而影响肾小球等肾脏器官的正常功能。
英文摘要:
      Objective To investigate the effect of high-salt diet on kidney tissue damage ofrats with salt-sensitive hypertension. Methods Twenty experimental rats were divided into control group (SS-13BNrats, n=10) and salt-sensitive hypertensive rat model group (Dahl/SS rats, n=10) according to rat type. The salt-sensitive hypertensive rat model was constructed by feeding a high salt feed containing 8% salt. The degree of kidney tissue damage and the expression of IL-6,IL-1β and TNF-α in kidney tissues of the two groups ratswere assessed. Results The systolic blood pressure in model group was(183.82±3.87)mmHg, that of the control group was (129.03±3.94)mmHg,and the difference was statistically significant (P<0.05). The nephrinuria content in kidney tissues of model group was (12.12±0.92) mg/d, the kidney injury degree score was (1.93±0.52), the content of TNF-α in the kidney tissue was (623.14±43.12) pg/mg, which were higher than that of the control group, and the differences were statistically significant (P<0.05). The relative mRNA expression levels of IL-6 in kidney tissues of model group was (2.25±0.81) and IL-1β was (2.89±0.86), which were higher than those of control group, and the differences were statistically significant (P<0.05).The protein relative expression levels of IL-6 in kidney tissues of model group was(1.71±0.08), and IL-1β was (2.23±0.13), which were higher than those of control group, and the differences were statistically significant (P<0.05). Conclusion High salt intake can cause serious damage to the kidneys of salt-sensitive rats, leading to inflammation and affecting the normal function of kidney organs such as glomeruli.
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