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| 高盐饮食对盐敏感性高血压大鼠肾脏损伤的影响 |
| Effects of high salt diet on kidney injury ofrats with salt-sensitive hypertension |
| 投稿时间：2020-02-12 |
| DOI：10.3969/j.issn.1000-0399.2020.08.002 |
| 中文关键词: 盐敏感性高血压 炎症 白介素-6 白介素-1β 肿瘤坏死因子-α 肾脏 |
| 英文关键词: Salt-sensitive hypertension Inflammation Interleukin 6 Interleukin 1β Tumor necrosis factor α Kidney |
| 基金项目:陕西省自然科学基础研究计划（项目编号：S2017-ZRJJ-MS-2212） |
| 作者 | 单位 | E-mail | | 任洁 | 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室 | | | 胡经文 | 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室 | | | 郭统帅 | 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室 | | | 何明俊 | 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室 | | | 刘富强 | 710068 西安 陕西省人民医院心内科 | | | 牟建军 | 710061 陕西西安 西安交通大学第一附属医院心血管内科, 陕西省分子心脏病学重点实验室, 环境与疾病相关基因教育部重点实验室 | mujjun@163.com |
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| 中文摘要: |
| 目的 研究高盐饮食对盐敏感性高血压大鼠肾脏组织损伤的影响。方法 将20只实验大鼠按照大鼠品系分为对照组（SS-13BN大鼠，n=10）与盐敏感性高血压大鼠模型组（Dahl/SS大鼠，n=10），通过喂食盐含量为8%的高盐饲料构建盐敏感性高血压大鼠模型，分析两组大鼠肾脏组织损伤程度及肾脏组织中白介素-6（IL-6）、白介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）的表达情况。结果 模型组大鼠的收缩压为（183.82±3.87）mmHg，对照组为（129.03±3.94）mmHg，差异有统计学意义（P<0.05）。模型组大鼠肾脏组织中Nephrinuria含量为（12.12±0.92）mg/d、肾损伤程度评分为（1.93±0.52）分、TNF-α含量为（623.14±43.12）pg/mg，均高于对照组，差异有统计学意义（P<0.05）。模型组大鼠肾脏组织中IL-6 mRNA的相对表达量为（2.25±0.81）、IL-1β mRNA为（2.89±0.86），均高于对照组，差异有统计学意义（P<0.05）。模型组大鼠肾脏组织中IL-6蛋白相对表达量为（1.71±0.08）、IL-1β为（2.23±0.13），均高于对照组，差异有统计学意义（P<0.05）。结论 高盐摄取会对盐敏感大鼠的肾脏造成严重的损伤，引起炎症反应，从而影响肾小球等肾脏器官的正常功能。 |
| 英文摘要: |
| Objective To investigate the effect of high-salt diet on kidney tissue damage ofrats with salt-sensitive hypertension. Methods Twenty experimental rats were divided into control group (SS-13BNrats, n=10) and salt-sensitive hypertensive rat model group (Dahl/SS rats, n=10) according to rat type. The salt-sensitive hypertensive rat model was constructed by feeding a high salt feed containing 8% salt. The degree of kidney tissue damage and the expression of IL-6,IL-1β and TNF-α in kidney tissues of the two groups ratswere assessed. Results The systolic blood pressure in model group was(183.82±3.87)mmHg, that of the control group was (129.03±3.94)mmHg,and the difference was statistically significant (P<0.05). The nephrinuria content in kidney tissues of model group was (12.12±0.92) mg/d, the kidney injury degree score was (1.93±0.52), the content of TNF-α in the kidney tissue was (623.14±43.12) pg/mg, which were higher than that of the control group, and the differences were statistically significant (P<0.05). The relative mRNA expression levels of IL-6 in kidney tissues of model group was (2.25±0.81) and IL-1β was (2.89±0.86), which were higher than those of control group, and the differences were statistically significant (P<0.05).The protein relative expression levels of IL-6 in kidney tissues of model group was(1.71±0.08), and IL-1β was (2.23±0.13), which were higher than those of control group, and the differences were statistically significant (P<0.05). Conclusion High salt intake can cause serious damage to the kidneys of salt-sensitive rats, leading to inflammation and affecting the normal function of kidney organs such as glomeruli. |
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