| Objective To analyze the clinical outcome and risk factors of culture-negative LOS in premature infants with gestational age less than 34 weeks. Methods A retrospective analysis from May 2015 to April 2019 in our hospital was performed on gestational age less than 34 weeks of diagnosis of children with culture-negative LOS clinical data. They were divided into the cure group and the adverse outcome group according to clinical outcome. Then the clinical outcome and risk factors of poor prognosis at discharge were analyzed. Results A total of 159 children were included, with a survival rate of 93.71% (149/159) and an incidence of adverse outcomes of 38.99% (62/159). Among the 62 children with adverse outcomes, 10 died, and the remaining serious complications included NEC above stage II, stage III or above ROP, stage III-IV IVH, PVL, and BPD. The proportion of male children in adverse outcome group, breast-feeding time<1/2 hospital stay, mechanical ventilation>1 week, severe RDS, use of vasoactive drugs, and total antibiotic use time>3 weeks during hospitalization were all higher than those in cure group with statistically significant differences (P<0.05). The gestational age and birth weight of adverse outcome group were lower than that of cure group (P<0.05). The total duration of oxygen use, intravenous nutrition and NICU hospitalization in adverse outcome group were all higher than those in cure group (P<0.05). Logistic regression analysis showed that breast-feeding time<1/2 hospital stay, mechanical ventilation time>1 week, and total antibiotic use time>3 weeks during hospitalization were independent risk factors for adverse outcome at discharge of children with culture-negative LOS. Conclusion Increasing the rate of breast feeding, reducing the mechanical ventilation time and reasonable use of antibiotics may improve culture-negative LOS in children with clinical outcome. |
