文章摘要
阿奇霉素序贯疗法联合特布他林 维生素D治疗小儿肺炎的疗效
Observation on curative effect of azithromycin sequential therapy, terbutaline nebulized inhalation combined with vitamin D in treatment of pneumonia in children
投稿时间:2020-10-19  
DOI:10.3969/j.issn.1000-0399.2021.03.005
中文关键词: 维生素D  小儿,肺炎  特布他林  阿奇霉素  临床疗效
英文关键词: Vitamin D  Pediatric pneumonia  Terbutaline  Azithromycin  Clinical efficacy
基金项目:中华国际科学交流基金会专项基金(项目编号:Z2018LAH001)
作者单位
王雷 236700 安徽省亳州市利辛县人民医院儿科 
华山 230000 合肥 安徽省儿童医院呼吸内科 
丰小希 236700 安徽省亳州市利辛县人民医院儿科 
陆振 236700 安徽省亳州市利辛县人民医院儿科 
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中文摘要:
      目的 探讨阿奇霉素序贯疗法联合特布他林、维生素D治疗小儿肺炎的临床效果。方法 回顾性选取安徽省利辛县人民医院2019年8月至2020年6月收治的120例小儿肺炎患者,按照患儿采取的治疗方式不同分为观察组和对照组,各60例,对照组患儿采用阿奇霉素序贯疗法,观察组患儿在对照组的基础上采用特布他林雾化吸入联合维生素D治疗,均连续治疗2周。对比两组患儿主要临床症状改善时间,两组患儿的临床治疗总有效率及不良反应(恶心呕吐、寒战、腹泻、皮疹)发生情况,比较两组随访6个月后肺炎罹患率差异。结果 观察组患儿发热消失时间、咳嗽消失时间、呼吸正常时间、CRP正常时间、胸片阴影消失时间及住院时间均优于对照组,差异有统计学意义(P<0.05)。观察组患儿治疗有效率(96.7%)高于对照组(83.4%),不良反应发生率(21.7%)高于对照组(13.3%),随访6个月后罹患率(8.3%)低于对照组(15.0%),差异均有统计学意义(P<0.05)。结论 阿奇霉素序贯疗法及特布他林雾化吸入联合维生素D治疗小儿肺炎可显著缩短病程,提高疗效,减少复发,值得临床运用。
英文摘要:
      Objective To investigate the clinical effect of azithromycin sequential therapy, terbutaline nebulized inhalation combined with vitamin D in the treatment of pneumonia in children. Methods From August 2019 to June 2020, 120 pediatric pneumonia patients from Lixin County People’s Hospital in Anhui Province were divided into observation group and control group with 60 patients in each group. The control group was given azithromycin sequential therapy, and the observation group received terbutaline nebulized inhalation combined with vitamin D on the basis of the control group. After two weeks, the main clinical symptoms of the two groups of children were compared with the improvement time (fever disappearance time, cough disappearance time, breathing normal time, normal time of CRP, disappearance time of chest X-ray, hospitalization time), the treatment effect rates and adverse reactions of the two groups of children, and the recurrence rate (nausea and vomiting, shiver, diarrhea, erythry) of pneumonia after six months of follow-up were compared. Results The disappearance time of fever, cough disappearance, normal breathing time, normal CRP time, chest X-ray shadow disappearance time and hospital stay time of children in the observation group were significantly better than those of the control group, and the difference was statistically significant (P<0.05); the effective rate of treatment in the observation group was 96.7%, which was higher than that of the control group (83.4%), and the incidence of adverse reactions of children in the observation group was 21.7%, which was higher than that of the control group (13.3%), and the recurrence rate after six months was 8.3%, which was lower than that of the control group (15.0%), and the differences were statistically different (P<0.05). Conclusions The azithromycin sequential therapy, terbutaline nebulized inhalation combined with vitamin D in the treatment of pneumonia in children can significantly shorten the course of the disease, improve the curative effect and reduce recurrence. Thus, it is worth clinical application.
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