文章摘要
308 nm准分子光联合中药热敷对白癜风患者的疗效及对T细胞亚群与炎症因子的影响
Herbal fomentation combined with 308 nm excimer light on vitiligo and its effect on T cell subsets and inflammatory cytokines
投稿时间：2021-01-07  
DOI：10.3969/j.issn.1000-0399.2021.05.003
中文关键词: 白癜风  中药热敷  308 nm准分子光  T细胞亚群  炎症因子
英文关键词: Vitiligo  Herbal fomentation  308 nm excimer light  T cell subsets  Inflammatory cytokines
基金项目:开封市科技攻关基金项目（项目编号：1906007）
作者单位E-mail
古月 475000 河南省开封市人民医院皮肤科  
王哲新 475000 河南省开封市人民医院皮肤科 kfwzx1020@163.com 
于子红 475000 河南省开封市人民医院皮肤科  
耿庆娜 475000 河南省开封市人民医院皮肤科  
王慧娟 475000 河南省开封市人民医院皮肤科  
吴德福 475000 河南省开封市人民医院皮肤科  
摘要点击次数: 1070
全文下载次数: 0
中文摘要:
      目的 探究308 nm准分子光联合中药热敷对治疗白癜风的疗效及对患者T细胞亚群与炎症因子的影响。方法 选取2018年5月至2020年5月于开封市人民医院皮肤科治疗的白癜风患者98例，根据随机数字表法分为两组，各49例，对照组进行308 nm准分子光治疗，观察组进行308 nm准分子光联合中药热敷治疗，比较两组临床疗效，分别于治疗前、治疗后3个月、治疗后6个月观察两组患者白斑面积、CD4+、CD8+、CD4+/CD8+、白介素-17（IL-17）、肿瘤坏死因子-a （TNF-α）、γ-干扰素（IFN-γ）变化及不良反应发生情况。结果 治疗后，观察组总有效率为97.96%，对照组为91.84%，差异有统计学意义（P<0.05）。两组CD4+、CD4+/CD8+、IL-17、TNF-α、IFN-γ水平存在时点、组间、时点与组别的交互效应（P<0.05）。治疗前两组各指标比较，差异均无统计学意义（P>0.05）。治疗后3、6个月，观察组CD4+、CD4+/CD8+较治疗前增高，且高于对照组，而CD8+、IL-17、TNF-α、IFN-γ较治疗前降低，且低于对照组，差异均有统计学意义（P<0.05）。结论 308 nm准分子光联合中药热敷治疗白癜风能有效提高临床疗效，并调节患者免疫功能，降低其机体炎症反应，值得临床推广。
英文摘要:
      Objective To investigate the clinical efficacy of herbal fomentation combined with 308nm excimer light in the treatment of vitiligo and the effects on T cell subsets and inflammatory cytokines.Methods A total of 98 patients with vitiligo treated in the Dermatology Department of Kaifeng People's Hospital from May 2018 to May 2020 were selected and divided into two groups with 49 patients in each group according to random number table method. The control group was treated with 308 nm excimer light therapy, and the observation group received herbal fomentation combined with 308 nm excimer light therapy. The leukoplakia area, CD4+, CD8+, CD4+/CD8+ levels, IL-17 were recorded before treatment, 3 months after treatment, and 6 months after treatment, and TNF-α, IFN-γ levels and occurrence of adverse reactions were assessed. Results After treatment the total effective rate of clinical curative effect was 97.96% in observation group and 91.84% in control group, and the difference was statistically significant(P<0.05).Also there were statistically significant differences in the interaction effects of CD4+, CD4+/CD8+, IL-17, TNF-α and IFN-γ of the two groups between different time points, between groups and between time points and groups (P<0.05). Before treatment, there was no significant difference in each index between the two groups (P>0.05).Three and six months after treatment, the increase degree of CD4+ and CD4+/CD8+ inobservation group was higher than that before treatment,and higher than that in control group, but the degrees of IL-17, TNF-α and IFN-γ in observation group was lower than those before treatment,and lower than those in control group, and all the differences were statistically significant (P<0.05). Conclusions Herbal fomentation combined with 308 nm excimer light in the treatment of vitiligo can effectively improve the clinical efficacy, reduce the occurrence of adverse reactions, effectively regulate the immune functionand improve the stability of the immune system. Thus it is worth clinical promotion.
查看全文   查看/发表评论  下载PDF阅读器
关闭