| Objective To investigate the differences in hematological indexes and cell morphology between myelodysplastic syndrome(MDS) and megaloblatic anemia(MA) patients. Methods From July 2015 to June 2020,17 newly diagnosed MDS patients and 18 MA patients were selected. The results of blood routine test, biochemical examination and bone marrow smear were compared between the two groups. Results Among 17 patients with myelodysplastic syndrome and 18 with megaloblatic anemia, there were no significance differences in the levels of white blood cell count, platelet count, hemoglobin, mean corpuscular volume, total bilirubin and indirect billirubin. The levels of serum lactate dehydrogenase in MA group was significantly higher than those in MDS group, but the level of serum SF was significantly lower than that in MDS group(P<0.05).In the bone marrow of MA group, megaloblastic changes of middle late erythroblastic were predominant in erythroid cells, while in MDS group, there were also H-J corpuscle, binucleate phenotypes and multinucleate cells in addition to middle late erythrocytic megaloblasty. Both MA and MDS showed different degrees of morbid hematopoiesis, including imbalance of nucleocytoplasmic development, nuclear swelling and cytoplasmic granule reduction. The rates of primitive cell(76.47%) and lymphoid micromegakaryocyte(47.06%) increasing in MDS were significantly higher than in MA(P<0.05). Conclusions The combination of hematological indexes with bone marrow cytology is conducive to the different ialdiagnosis of myelodysplastic syndrome and megaloblastic anemia. |
