| Objective To understand the resistance and distribution characteristics of methicillin-resistant staphylococcus aureus(MRSA) and provide basis for infection prevention and clinical anti-infection treatment. Methods The detection, infection characteristics, drug sensitivity test of staphylococcus aureus (SA) and MRSA in the Affiliated Hospital of Gansu Medical College from 2015 to 2019 were evaluated by the K-B method. Results From 2015 to 2019, a total of 1 241 strains of SA were isolated, including 108 strains (32.31%) of MRSA. Dynamic monitoring showed that the MRSA separation rate decreased from 39.26% in 2014 to 27.19% in 2018 (P<0.05). The detection rate of MRSA increased with the age of patients, and the detection rate of patients >65 years old was significantly higher than that of patients<40 years old (P<0.05). MRSA specimens were mainly from cerebrospinal fluid (41.18%), secretions (38.52%), sputum (35.11%) and whole blood (33.18%); the infection department mainly consisted of ICU (41.18%), neurosurgery (41.89%), and respiratory medicine (34.06%) and orthopedics burns (32.89%) more common. Drug sensitivity showed that the resistance of MRSA to penicillin was 100.00%, resistance to gentamicin, clindamycin and tetracycline was greater than 80%, for Moxifloxacin, Rifampicin, Amikacin and Compound of Sulfamethoxazole was between 40%~50%, and no MRSA strain resistant to Vancomycin or Linezolid was found. Dynamic testing showed that from 2015 to 2019 the resistance rate of MRSA to Levofloxacin and Moxifloxacin showed a downward trend, and Amikacin and Compound of Sulfamethoxazole an increased trend, and Rifampicin was basically stable. Conclusions The detection rate of MRSA in the hospital shows a downward trend. The ICU, neurosurgery, respiratory medicine and orthopedics burn department arehigh-risk departments. MRSA is multi-drug resistant, and no vancomycin-resistant MRSA strain has been found. |
