文章摘要
低分子肝素治疗胎儿生长受限的效果及对胎儿窘迫发生率的影响
Effect of low molecular weight heparin in treatment of fetal growth restriction and its influence on incidence of fetal distress
投稿时间：2021-04-19  
DOI：10.3969/j.issn.1000-0399.2021.10.006
中文关键词: 低分子肝素  胎儿生长受限  胎儿窘迫  新生儿结局
英文关键词: Low molecular weight heparin  Fetal growth restriction  Fetal distress  Neonatal outcome
基金项目:河北省2019年度医学科学研究课题计划（项目编号：20191527）
作者单位
陈莹 063000 河北省唐山市妇幼保健院妇产科 
汪俊红 063000 河北省唐山市妇幼保健院妇产科 
刘丹 063000 河北省唐山市妇幼保健院妇产科 
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中文摘要:
      目的 探讨低分子肝素治疗胎儿生长受限的效果及对胎儿窘迫发生率的影响。方法 选取2018年9月至2020年10月河北省唐山市妇幼保健院接受治疗，并诊断为胎儿生长受限的孕妇248例，根据随机数字表法分为对照组和观察组，各124例。对照组均接受常规基础治疗，观察组在对照组基础上同时接受低分子肝素治疗，7天一个疗程，1个疗程后休息7天，再进行下一个疗程，共治疗3个疗程。对比分析两组治疗前后双顶径、头围、宫高、腹围各项生长发育情况，治疗结束后，观察两组临床治疗有效率及胎儿窘迫、早产、新生儿窒息发生情况。结果 观察组胎儿双顶径、头围、宫高、腹围各项生长发育变化情况明显优于对照组（t=17.296、24.151、21.634、27.987，P均<0.05）。观察组临床治疗有效率（97.58%）明显高于对照组（73.39%），差异有统计学意义（χ2=29.245，P<0.001）。观察组胎儿窘迫、早产、新生儿窒息发生率均明显低于对照组（χ2=9.621、11.741、7.705，P均<0.05）。结论 低分子肝素治疗胎儿生长受限临床疗效明显，能够显著降低胎儿窘迫等不良妊娠结局发生情况，促进胎儿生长发育。
英文摘要:
      Objective To explore and analyze the effect of low molecular weight heparin on fetal growth restriction and its influence on the incidence of fetal distress. Methods A total of 248 pregnant women admitted to our hospital for treatment from September 2018 to October 2020 were selected. The pregnant women in the control group received routine basic treatment, and the observation group received low-molecular-weight heparin treatment at the same time, with a course of seven days, a 7-day rest after the first course, and the next course of treatment for a total of three courses. The weekly biparietal diameter, head circumference, uterine height, and abdominal circumference of the two groups were compared and analyzed. The efficiency, neonatal fetal distress, premature birth, and neonatal asphyxia of the clinical treatment were compared and analyzed. Results The weekly biparietal diameter, head circumference, uterine height, and abdominal circumference of the observation group were significantly better than those of the control group (t=17.296, 24.151, 21.634, 27.987, P<0.001). The effective rate of clinical treatment in the observation group was 97.58%, which was significantly higher than that in the control group (73.39%) (χ2=29.245, P<0.001). The incidence of neonatal fetal distress, premature delivery, and neonatal asphyxia in the observation group were significantly lower than those in the control group (χ2=9.621, 11.741, 7.705, P<0.05). Conclusions Low-molecular-weight heparin has a significant clinical effect in the treatment of FGR, which can markedly reduce the occurrence of fetal distress and adverse pregnancy outcomes, and promote fetal growth and development.
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