文章摘要
2型糖尿病患者肾糖阈的性别差异及相关因素分析
Analysis of gender differences and related factors of renal glucose threshold in patients with type 2 diabetes
投稿时间：2021-06-22  
DOI：10.3969/j.issn.1000-0399.2021.12.004
中文关键词: 肾糖阈  糖尿病  2型  性别
英文关键词: Renal glucose threshold  Diabetes mellitus  type 2  Gender
基金项目:阜阳市卫生计生委课题（项目编号：2016FY05）
作者单位
申金付 236000 安徽省阜阳市人民医院内分泌科 
张学辉 236000 安徽省阜阳市人民医院内分泌科 
霍琴琴 236000 安徽省阜阳市人民医院内分泌科 
张梦洁 236000 安徽省阜阳市人民医院内分泌科 
冯双双 236000 安徽省阜阳市人民医院内分泌科 
蒋瑞妹 236000 安徽省阜阳市人民医院内分泌科 
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中文摘要:
      目的 分析2型糖尿病患者肾糖阈（RTG）的性别差异及相关因素。方法 选取阜阳市人民医院内分泌科住院的114例2型糖尿病患者，分男性组（n=57）与女性组（n=57），公式法得到患者的RTG，比较并分析男女患者的RTG、生化及临床资料。结果 2型糖尿病患者平均RTG值为（11.25±2.68） mmol/L；两组患者的RTG值、RTG分类、年龄、病程、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）及血糖平均值（MBG）的差异有统计学意义（P<0.05），空腹血糖、糖化血红蛋白（HbA1c）、空腹C肽、胆固醇（CHO）、三酰甘油（TG）、血肌酐、尿酸、24 h尿糖、身体质量指数（BMI）及高血压病史差异无统计学意义（P>0.05）。线性回归分析显示，BMI （β=0.379，95% CI：0.272~0.487）、HbA1c （β=0.668，95% CI：0.471~0.866）和性别（β=1.912，95% CI：1.164~2.661）是2型糖尿病患者RTG的影响因素；BMI （β=0.314，95% CI：0.156~0.437）和HbA1c （β=0.643，95% CI：0.387~0.900）是男性2型糖尿病患者RTG的影响因素；BMI （β=0.425，95% CI：0.272~0.578）是女性2型糖尿病患者RTG的影响因素（P<0.05）。结论 性别是2型糖尿病患者RTG的影响因素，女性的RTG值高于男性。
英文摘要:
      Objective To investigate the gender differences and related factors of renal glucose threshold (RTG) in patients with type 2 diabetes.Methods A total of 114 patients with type 2 diabetes hospitalized in the Department of Endocrinology, Fuyang People's Hospital were divided into the male groups (n=57) and the female groups (n=57). The RTG of the patients was obtained by formula method. The renal glucose threshold, biochemical and clinical data of male and female patients were compared and analyzed.Results The average RTG value of diabetic patients was (11.25±2.68) mmol/L. The RTG value, RTG classification, age, course of disease, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C) and blood glucose mean (MBG) of the two groups of patients were different (P<0.05), while fasting blood glucose, glycosylated hemoglobin (HbA1c), fasting C-peptide, cholesterol (CHO), triglycerides (TG), blood creatinine, uric acid, 24 h urine glucose, body mass index (BMI) and history of hypertension were not different (P>0.05). Linear regression analysis showed that BMI (β=0.379, 95%CI:0.272~0.487), HbA1c (β=0.668, 95%CI:0.471~0.866) and gender (β=1.912, 95%CI:1.164~2.661) were the influencing factors of RTG in patients with type 2 diabetes; BMI (β=0.314, 95%CI:0.156~0.437) and HbA1c (β=0.643,95%CI:0.387~0.900) were the RTG of male patients with type 2 diabetes influencing factors; BMI (β=.4258, 95%CI:0.272~0.578) was influencing factors of RTG in female patients with type 2 diabetes (P<0.05). Conclusion Gender is an influencing factor for the RTG of patients with type 2 diabetes. The RTG value of women is higher than that of men.
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