| Objective To explore the predictive value of neutrophil/lymphocyte ratio (NLR) combined with miR-208a level in patients with acute ST-segment elevation myocardial infarction (STEMI) in patients with acute heart failure. Methods A collection of 148 patients with acute STEMI admitted to Fuwai Central China Cardiovascular Hospital from October 2018 to June 2020 were selected as the STEMI group, and 82 patients who had a healthy physical examination during the same period in the hospital were selected as the control group. The levels of NLR and miR-208a were compared between the two groups. Patients in the STEMI group were divided into AHF group with 38 cases and non-AHF group with 110 cases according to whether acute heart failure (AHF) occurred within 48 hours of admission. The clinical data, NLR and miR-208a levels of patients in the AHF group and the non-AHF group were compared, multivariate Logistic regression was used to analyze the influencing factors of AHF in STEMI patients, and the receiver operating characteristic curve (ROC) area under the curve (AUC) was used to evaluate the predictive value of NLR and miR-208a levels in STEMI patients with AHF. Results The levels of NLR and miR-208a (4.41±0.87, 27.88±5.42) of the STEMI group were significantly higher than those of the control group (1.52±0.38, 1.31±0.36), and the difference was statistically significant (t=28.586,44.294, all P<0.05). Multivariate logistic regression analysis showed that systolic blood pressure, serum hs-CRP, NLR and miR208a were the influencing factors of AHF in STEMI patients (P<0.05). NLR and serum miR-208a levels alone and in combination predicted the sensitivity and specificity of STEMI complicated by AHF:NLRwas 78.9%, 94.5%, miR-208a was 78.9%, 72.7%, combined detection was 86.8%, 85.5%, AUC was respectively 0.897, 0.817, 0.914.Conclusion NLR and serum miR-208a expression significantly increase in acute STEMI patients, with higher predictors of combined NLR and miR208a expression for concurrent AHF. |
