| Objective To investigate the clinical characteristics and prognostic factors for patients with glioblastoma.Methods The clinical data of 78 patients with glioblastoma (GBM) undergoing radio-chemotherapy following surgery from June 30, 2015 to December 13, 2017 in Anhui Provincial Cancer Hospital were analyzed retrospectively, including radiation doses, the number of adjuvant temozolomide (TMZ) cycles, extent of surgical resection, and immunohistochemical index. Kaplan-Meier method was performedto assess the survival rate. Cox regression model was used to analyze prognostic factors. Results Univariate analysis showed that KPS score before radiotherapy>60, gross total resection of tumor, and more than 6 cycles of adjuvant TMZ were significantly associated with longer progression-free survival (PFS) and the median overall survival time (OS) time of 78 patients with GBM(P<0.001), whereas the gender, age, radiation doses, the expression of IDH1, MGMT and Ki-67 had no significant impact on the PFS(P>0.05), and no significant effect on OS (P>0.05).There werethree variables with statistical significance in univariate analysis.None of their survival curves intersected significantly, which could be considered to meet the PH hypothesis. There variables were incorporated into multivariate Cox regression analysis, andin terms of OS, KPS score was statistically significant for the extension of OS (P<0.05).Moreover, KPS score and the extent of total resection significantly impacted the PFS (P=0.005、0.003, respectively) while the number of adjuvant TMZ cycles had no significant effect(P=0.109).Conclusions KPS score before radiotherapy, intraoperative resection, and the number of adjuvant chemotherapy cycles are independent prognostic factors for patients with glioblastoma. The higher KPS score, the intraoperative total resection, and the prolonged adjuvant chemotherapy cycle can significantly improve the patients' OS. |
