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| MicroRNA-590在急性心肌梗死诊断及预后评估中的价值 |
| Value of microRNA-590 in diagnosis and prognosis of patients with acute myocardial infarction |
| 投稿时间：2021-05-22 |
| DOI：10.3969/j.issn.1000-0399.2022.01.003 |
| 中文关键词: 心肌梗死 microRNA-590 诊断 预后 |
| 英文关键词: Myocardial infarction MicroRNA-590 Diagnosis Prognosis |
| 基金项目:安徽省高等学校自然科学研究重点项目（项目编号：KJ2018A0814），安徽省卫生计生委科研计划项目（项目编号：2018SEYL008） |
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| 中文摘要: |
| 目的 研究microRNA-590（miR-590）在急性心肌梗死（AMI）诊断及预后评估中的价值。方法 选择2018年5月至2019年10月安徽省第二人民医院心内科收治的患者162例，根据临床诊断及冠状动脉造影结果，分为对照组（HC组，n=40）、稳定型心绞痛（SAP）组（n=50）和AMI组（n=72），收集临床资料，运用定量逆转录聚合酶链反应检测各组血浆miR-590的表达水平，定期随访并记录患者出院后1年内主要不良心血管事件发生情况。结果 AMI组患者血浆miR-590水平为（1.66±0.44）、cTnI水平为[5.17（1.20，16.85）]ng/mL、CK-MB水平为[45.00（35.25，68.00）]U/L，均高于SAP组和HC组，差异有统计学意义（P<0.05），SAP组和HC组血浆miR-590、cTnI及CK-MB水平差异均无统计学意义（P>0.05）。Spearman相关性分析显示，AMI患者血浆miR-590水平与cTnI（r=0.751，P<0.001）及CK-MB（r=0.692，P<0.001）均呈正相关。根据血浆miR-590水平中位数，将AMI组患者分为低miR-590组与高miR-590组，高miR-590组AMI患者1年内心力衰竭及主要不良心血管事件发生率高于低miR-590组（P=0.015）。结论 血浆miR-590作为AMI诊断和预后评估的生物标志物具有重要的临床意义。 |
| 英文摘要: |
| Objective To investigate the value of microRNA-590 (miR-590) in the diagnosis and prognosis of patients with acute myocardial infarction (AMI).Methods A total of 162 patients admitted to the Department of Cardiology of Anhui No.2 Provincial People's Hospital from May 2018 to October 2019 were divided into control group(HC, n=40), stable angina pectoris group(SAP, n=50) and acute myocardial infarction group(AMI, n=72) according to the results of clinical diagnosis and coronary angiography. The clinical data were collected and the expression level of miR-590 was detected by quantitative reverse transcriptase-polymerase chain reaction. All patients were followed up for main adverse cardiovascular events within one year after discharge.Results The plasma levels of miR-590(1.66±0.44), cTnI[5.17 (1.20, 16.85)]ng/mL and CK-MB[45.00 (35.25, 68.00)]U/L in AMI group patientswere higher than those in SAP group and HC group, andthe differences were statistically significant(P<0.05). There were no significant differences in plasma miR-590, cTnI and CK-MB levels between SAP group and HC group(P>0.05). Spearman correlation analysis showed that plasma miR-590 levels in AMI patients were positively correlated with cTnI(r=0.751, P<0.001) and CK-MB(r=0.692, P<0.001). The patients in AMI group were divided into low miR-590 group and high miR-590 group according to the median level of plasma miR-590, andthe incidence of heart failure and major adverse cardiovascular events in high miR-590 group was higher than that in low miR-590 group within one year(P=0.015).Conclusion Plasma miR-590 plays an important role as a biomarker both in diagnosis of AMI and in evaluation of its prognosis. |
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