文章摘要
超重2型糖尿病心外膜脂肪厚度与血浆致动脉硬化指数关系
Relationship between thickness of epicardial fat and atherosclerosis index of plasma in overweight type 2 diabetes
投稿时间：2021-04-12  
DOI：10.3969/j.issn.1000-0399.2022.01.012
中文关键词: 超重  2型糖尿病  心外膜脂肪  血浆致动脉硬化指数
英文关键词: Overweight  Type 2 diabetes  Epicardial fat  Arteriosclerosisindex of plasma
基金项目:
作者单位E-mail
胡国平 230061 安徽合肥 安徽医科大学第三附属医院内分泌科  
马维青 230061 安徽合肥 安徽医科大学第三附属医院内分泌科  
王国娟 230061 安徽合肥 安徽医科大学第三附属医院内分泌科  
司玮 230061 安徽合肥 安徽医科大学第三附属医院内分泌科  
张强 230061 安徽合肥 安徽医科大学第三附属医院内分泌科  
孙春萍 230061 安徽合肥 安徽医科大学第三附属医院内分泌科  
刘皆 230061 安徽合肥 安徽医科大学第三附属医院内分泌科  
张伟 230061 安徽合肥 安徽医科大学第三附属医院内分泌科  
杨孝孝 230061 安徽合肥 安徽医科大学第三附属医院内分泌科  
吕芳 230061 安徽合肥 安徽医科大学第三附属医院内分泌科 doctorlvf@126.com 
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中文摘要:
      目的 探讨超重2型糖尿病（T2DM）患者心外膜脂肪（EAT）厚度与血浆致动脉硬化指数（AIP）之间的关系。方法 选取2018年1月至2020年11月安徽医科大学第三附属医院内分泌科139例T2DM患者，依据身体质量指数（BMI）分为正常体质量组（NW，76例，BMI 18.5~23.9 kg/m2），超重组（OW，63例，BMI 24~27.9 kg/m2）。检测并比较两组患者临床及生化指标，采用心脏超声检测两组患者EAT厚度，Pearson相关和多元逐步线性回归分析EAT厚度、中性粒细胞与淋巴细胞之比（NLR）、血小板与淋巴细胞之比（PLR）与AIP之间的关系。结果 ①OW组体质量、BMI、三酰甘油（TG）、空腹C肽（FCP）、白细胞计数（WBC）、淋巴细胞计数（L）、NLR、PLR、AIP、EAT均高于NW组，差异有统计学意义（P<0.05）；其他临床、生化指标差异无统计学意义。②Pearson相关分析显示，两组患者EAT厚度与年龄、BMI、TG、AIP呈正相关（r=0.394，0.277，0.371，0.333，P<0.01），与高密度脂蛋白胆固醇（HDL-c）呈负相关（r=-0.079，P<0.05）；两组患者AIP与BMI、WBC、N、NLR、PLR、TG、血尿酸（UA）、EAT厚度呈正相关（r=0.590，0.223，0.221，0.289，0.226，P<0.05或P<0.01），与HDL-c呈负相关（r=-0.459，P<0.05）；OW组AIP与BMI、NLR、PLR、TG、UA、EAT厚度呈正相关（r=0.170，0.329，0.423，0.832，0.309，0.531，P<0.05或P<0.01），与HDL-c、极低密度脂蛋白胆固醇（VLDL-c）负相关（r=-0.459，-0.354，P均<0.01）。③多元线性逐步回归分析显示，OW组AIP与BMI（95% CI：0.097~0.979，P=0.018）、EAT厚度（95% CI：2.019~6.212，P=0.009）、TG（95% CI：0.131~0.187，P<0.001）存在危险因素关联。结论 超重2型糖尿病患者EAT厚度增加，EAT厚度、TG、BMI是影响AIP的危险因素。
英文摘要:
      Objective To investigate the relationship between epicardial adipose tissue (EAT) thickness and arteriosclerosis index of plasma (AIP) in patients with overweight type 2 diabetes. Methods From January 2018 to November 2020, 139 patients with T2DM in the Department of Endocrinology, the Third Affiliated Hospital of Anhui Medical University were selected and divided into the normal body mass group (NW, 76 cases, BMI:18.5~23.9 kg/m2) and super-recombination (OW, 63 cases, BMI:24~27.9 kg/m2) according to the body mass index (BMI). The clinical and biochemical indicators of the two groups of patients were detected and compared. The EAT thickness of the two groups was detected by echocardiography. Pearson correlation and multiple stepwise linear regression were used to analyze the EAT thickness, the ratio of neutrophils to lymphocytes (NLR), and the ratio of platelets to lymphocytes (PLR) and the relationship between AIP.Results ①Body mass, BMI, TG, FCP, WBC, L, NLR, PLR, AIP, EAT in OW group were higher than those in NW group, and the difference was statistically significant (P<0.05); there was no significant difference in other clinical and biochemical indexes.②Pearson correlation analysis showed that EAT thickness was positively correlated with age, BMI, TG and AIP (r=0.394, 0.277, 0.371, 0.333, P<0.01), and negatively correlated with high density lipoprotein cholesterol(HDL-C) (r=-0.079, P<0.05).AIP was positively correlated with BMI, WBC, N, NLR, PLR, TG, blood uric acid (UA) and EAT thickness (r=0.590, 0.223, 0.221, 0.289, 0.226, P<0.05 or P<0.01), and negatively correlated with HDL-C (r=-0.459, P<0.05).AIP in OW group was positively correlated with BMI, NLR, PLR, TG, UA and EAT thickness (r=0.170, 0.329, 0.423, 0.832, 0.309, 0.531, P<0.05 or P<0.01), and negatively correlated with HDL-C and very low density lipoprotein cholesterol (VLDL-C) (r=-0.459, -0.354, P<0.01).③Multiple linear stepwise regression analysis showed that AIP was associated with BMI (β=0.538, P=0.018, 95%CI:0.097~0.979), EAT thickness (β=4.162, P=1.026, 95%CI:2.019~6.212), TG (β=0.159, P<0.001, 95%CI:0.131~0.187) in OW group.Conclusion The thickness of EAT increases in overweight patients with type 2 diabetes. EAT thickness, TG and BMI are risk factors for AIP.
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