| Objective To explore the clinical efficacy and safety of hydroxychloroquine combined with electro-optical synergy technique in the treatment of rosacea. Methods The clinical data of 92 rosacea patients admitted to our hospital from May 2020 to April 2021 were retrospectively analyzed, and patients were divided into two groups according to the random number table. Study group (n=48) received hydroxychloroquine combined with electro-optical synergy technique, while control group (n=44) received hydroxychloroquine only. The scores of Physician's Global Assessment (PGA), erythema, papule and other symptoms, and quality of life were recorded. Meantime, the clinical efficacy and adverse reaction rate were compared between the two groups. Results The clinical efficacy rate was 93.75% in study group, which was significantly higher than 77.27% in control group (P<0.05). Compared with baseline data, the changes in the scores of PGA, erythema, papule, pustule and pruritus at post-treatment 4 months were more greater in study group than in control group (P<0.05). The incidence rate of adverse reaction rate was 4.17% in study group, which was slightly lower than 9.09% in control group, with no statistical difference (P>0.05). Conclusion Compared with hydroxychloroquine treatment alone, its combination with electro-optical synergy technique in the treatment of rosacea achieves better effect on erythema, telangiectasia, papules, pustules and pruritus, which is worthy of clinical application. |
