文章摘要
33例肺肉瘤样癌患者临床病理特征与生存率的关系
Correlation analysis of clinicopathological features and survival rate of 33 patients with pulmonary sarcomatoid carcinoma
投稿时间：2021-07-14  
DOI：10.3969/j.issn.1000-0399.2022.04.006
中文关键词: 肺肉瘤样癌  病理特征  回顾性分析  生存分析。
英文关键词: Pulmonary sarcomatoid carcinoma  Pathological characteristics  Retrospective analysis  Survival analysis
基金项目:安徽省自然科学基金（项目编号:90326774011）
作者单位
钟锋 230031 安徽合肥 安徽省肿瘤医院急诊内科 
唐浩 230031 安徽合肥 安徽省肿瘤医院呼吸肿瘤科 
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中文摘要:
      目的 分析肺肉瘤样癌（PSC）患者临床、病理特征与生存率的关系。方法 回顾性分析安徽省立医院2015年9月至2021年6月收治的33例PSC患者资料，包括患者基础资料、临床症状、肿瘤特征和分期、病理特点以及治疗方式等。依据肿瘤直径（>7 cm、≤7 cm）、肿瘤分期（TNM分期）、病理特征[波形蛋白（ VIM）、细胞角蛋白（CK）、甲状腺转录因子-1（TTF -1）、细胞核增殖抗原（Ki -67）]等对研究对象分组，χ2检验比较组间生存率；Kaplan-Meier法绘制生存曲线，Log-rank法比较组间生存情况。结果 共纳入PSC患者33例，5年生存率6.06%，临床症状以咳嗽（75.8%）、咯血（48.5%）为主。不同性别、年龄、是否吸烟患者间3年和5年生存率比较，差异无统计学意义（χ2=0.798、0.391、0.926，P均>0.05）。肿瘤直径≤7 cm患者累积生存率高于肿瘤直径>7 cm的患者（χ2=5.239，P=0.022）。M0分期患者累积生存率高于M1分期患者（χ2=9.494，P=0.002）；无肿瘤转移患者的累积生存率高于有转移的患者，差异有统计学意义（χ2=7.838，P=0.005）。Ki-67弱表达（<70%）患者累积生存率高于强表达患者（χ2=8.545，P=0.004）。VIM、CK和TTF-1阳性患者累积生存率与相应阴性患者比较，差异无统计学意义（P均>0.05）。不同治疗方式患者的3年和5年生存率比较，差异无统计学意义（P均>0.05）。结论 肿瘤直径、M分期、Ki-67表达情况影响PSC患者生存率，可作为判断患者预后的潜在指标。
英文摘要:
      Objective To analyze the correlation between clinical/pathological features and survival rate of patients with pulmonary sarcomatoid carcinoma (PSC).Methods The clinical data (patient basic data, clinical symptoms, tumor characteristics and stages, pathological characteristics and treatment methods) of 33 patients with PSC in Anhui ProvincialHospital from September 2015 to June 2021 were analyzed retrospectively. The subjects were grouped by tumor diameter (>7 cm, ≤ 7 cm), tumor stage (TNM stage) and pathological features[Vimentin (VIM), cytokeratin (CK),thyroid transcription factor (TTF-1) and Ki -67)].χ2 test method was used to compare the survival rates of patients in different groups.Kaplan-Meier method was used to draw the survival curve, and Log-rank method was used to compare the survival rates between groups.Results There was no significant difference in the 3-year and 5-year survival rates among patients with different gender, age and smoking status (χ2=0.798, 0.391, 0.926, all P>0.05).The cumulative survival rate of patients with tumor diameter less than 7cm was higher than that of patients with tumor diameter greater than 7 cm (χ2=5.239, P=0.022).The cumulative survival rate of patients with M0 stage was higher than that of patients with M1 stage(χ2=9.494,P=0.002). The cumulative survival rate of patients without tumor metastasis was significantly higher than that of patients with metastasis (χ2=7.838,P=0.005). The cumulative survival rate of patients with weak ki-67 expression (<70%) was significantly higher than that of patients with high expression (χ2=8.545, P=0.004).There was no significant difference in cumulative survival rate between VIM, CK and TTF-1 positive patients and corresponding negative patients (all P>0.05).There was no significant difference in 3-year and 5-year survival rates among patients with different treatment methods (all P>0.05).Conclusion Tumor diameter, M stage and Ki-67 expression affect the survival rate of PSC patients, which may be used as potential indicators to judge the prognosis of patients.
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