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| 稽留流产后再次妊娠的妊娠结局及其影响因素分析 |
| Analysis of pregnancy outcome and its influencing factors after missed abortion |
| 投稿时间：2021-12-26 |
| DOI：10.3969/j.issn.1000-0399.2022.06.005 |
| 中文关键词: 稽留流产 妊娠结局 妊娠期合并症 妊娠期并发症 |
| 英文关键词: Missed abortion Pregnancy outcome Gestational co-morbidities Gestational complications |
| 基金项目:安徽省卫生健康委科研项目(项目编号:AHWJ2021b113) |
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| 中文摘要: |
| 目的 探讨稽留流产后再次妊娠的妊娠结局及其影响因素。方法 选取2014年1月至2019年6月于安徽省第二人民医院妇科行药流清宫术的360例稽留流产患者(观察组),以及同时期就诊于安徽省第二人民医院妇科要求终止妊娠行药流清宫术的120例正常早孕患者(对照组),两组患者均再次妊娠,分别对观察组和对照组再次妊娠的妊娠结局,以及相关妊娠期合并症并发症情况进行统计分析。结果 观察组和对照组异位妊娠、胎儿畸形引产、早产、过期妊娠和胎儿窘迫发生率比较,差异均无统计学意义(P>0.05);观察组的自然流产率高于对照组(17.22% 比 7.50%),足月产率低于对照组(72.50% 比 83.33%),差异有统计学意义(P<0.05);两组对象的甲亢、亚临床甲减、甲减、妊娠期糖尿病、妊娠期高血压疾病、妊娠期贫血、胎膜早破、产后出血的发生率比较,差异无统计学意义(P>0.05);观察组的妊娠期阴道流血发生率高于对照组(23.61% 比 11.67%),差异有统计学意义(P<0.05);logistic回归分析结果显示,甲亢、亚临床甲减及甲减是稽留流产后再次妊娠发生自然流产的危险因素(P<0.05)。结论 稽留流产后再次妊娠的自然流产率增高,足月产率降低,再次妊娠时甲亢、亚临床甲减、甲减会增加自然流产的发生风险。 |
| 英文摘要: |
| Objective To analyze the pregnancy outcome and its influencing factors after missed abortion. Methods From January 2014 to June 2019, 360 patients with missed abortion who underwent medical abortion and curettage (observation group) in the Department of Gynecology of Anhui No.2 Provincial People’s Hospital were selected, and 120 women with normal early pregnancy who underwent medical abortion and curettage during the same period were selected as control group. Women in the two groups all got pregnant again. The pregnancy outcome and related gestational co-morbidities and complications in the observation group and control group were statistically analyzed. Results There was no significant difference in the incidence of ectopic pregnancy, fetal malformation induced labor, premature birth, post-term pregnancy and fetal distress between the observation group and control group (P>0.05). The spontaneous abortion rate in the observation group was higher than that in control group (17.22% vs 7.50%), the full-term delivery rate in the observation group was lower than that in control group (72.50% vs 83.33%), and the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of hyperthyroidism, subclinical hypothyroidism, hypothyroidism, gestational diabetes mellitus, gestational hypertension, gestational anemia, premature rupture of membranes and postpartum hemorrhage between the two groups (P>0.05). The vaginal bleeding rate during pregnancy in the observation group was higher than that in control group (23.61% vs 11.67%), and the difference was statistically significant (P＜0.05). Logistic regression analysis showed that hyperthyroidism, subclinical hypothyroidism and hypothyroidism could increase the risk of spontaneous abortion after missed abortion(P＜0.05). Conclusions The spontaneous abortion rate increases, while full-term delivery rate decreases in women with pregnant after missed abortion. What’s more, hyperthyroidism, subclinical hypothyroidism, and hypothyroidism would increase the risk of spontaneous abortion in this situation. |
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