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| 地高辛治疗冠状动脉粥样硬化性心脏病伴房颤患者全因死亡Cox回归分析 |
| COX regression analysis on effects of digoxin on all-cause death in patients with coronary heart disease and atrial fibrillation |
| 投稿时间：2021-12-30 |
| DOI：10.3969/j.issn.1000-0399.2022.06.006 |
| 中文关键词: 地高辛 冠心病 心房颤动 全因死亡 |
| 英文关键词: Digoxin Coronary heart disease Atrial fibrillation All-cause death |
| 基金项目:河南省科技攻关联合共建项目(项目编号:LHGJ20190435),新乡医学院第一附属医院青年培育基金项目(项目编号:ON-2020-A01) |
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| 中文摘要: |
| 目的 探讨口服地高辛对冠状动脉粥样硬化性心脏病(CHD)伴房颤患者远期全因死亡风险的影响。方法 回顾性分析2015年5月至2018年5月新乡医学院第一附属医院收治的CHD伴房颤患者306例。根据是否口服地高辛分为口服地高辛组(n=97)和未口服地高辛组(n=209)。采用Kaplan-Meier曲线及log-rank检验比较两组患者的3年累积生存率,通过构建多因素Cox回归模型分析口服地高辛组患者全因死亡的危险因素。结果 截止2021年5月,共获得294例患者患者的生存资料,其中口服地高辛组93例,未口服地高辛组201例。口服地高辛组死亡32例,未口服地高辛组死亡19例;口服地高辛组患者3年累积生存率(65.59%)低于未口服地高辛组(90.54%)(HR=5.351,95%CI:2.909~9.843,P<0.05);多因素Cox回归分析矫正显示,口服地高辛是导致CHD伴房颤患者死亡危险因素(HR=2.444,95%CI:1.247~4.791,P<0.05)。结论 口服地高辛可能增加CHD伴房颤患者的全因死亡风险。 |
| 英文摘要: |
| Objective To explore the effects of oral digoxin on the risk of long-term all-cause death in patients with coronary heart disease (CHD) and atrial fibrillation. Methods A retrospective analysis was performed on the 306 patients with CHD and atrial fibrillation admitted to the First Affiliated Hospital of Xinxiang Medical College between May 2015 and May 2018. According to presence or absence of oral digoxin, they were divided into oral digoxin group (n=97) and non-oral digoxin group (n=209). The 3-year cumulative survival rate between the two groups was compared by Kaplan-Meier curves and log-rank test. The risk factors of all-cause death were analyzed by multivariate Cox regression model. Results As of May 2021, there were survival data of the 294 patients, including 93 cases in oral digoxin group and 201 cases in non-oral digoxin group. There were 32 death cases in oral digoxin group and 19 death cases in non-oral digoxin group. The 3-year cumulative survival rate in oral digoxin group was lower than that in non-oral digoxin group (65.59% vs 90.54%) (log-rank χ2=29.10, HR=5.351, 95%CI:2.909~9.843, P<0.05). Cox multivariate regression analysis showed that oral digoxin was a risk factor of death in patients with CHD and atrial fibrillation (HR=2.444, 95%CI:1.247~4.791,P<0.05). Conclusion Oral digoxin may increase the risk of all-cause death in patients with CHD and atrial fibrillation. |
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