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| 他克莫司与曲安奈德治疗口腔扁平苔癣的临床研究 |
| The clinical study of tacrolimus and triamcinolone acetonide in treatment of oral lichen planus |
| 投稿时间：2021-11-14 |
| DOI：10.3969/j.issn.1000-0399.2022.06.010 |
| 中文关键词: 口腔扁平苔癣 外用 他克莫司 曲安奈德 |
| 英文关键词: Oral lichen planus Topical Tacrolimus Triamcinolone acetonide |
| 基金项目:安徽省重点研究与开发项目(项目编号:202104j07020038) |
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| 中文摘要: |
| 目的 探讨局部外用他克莫司膏与曲安奈德对口腔扁平苔藓(OLP)的临床疗效。方法 选取2019年6月至2019年12月于安徽医科大学第一附属医院口腔科就诊的60例OLP患者作为研究对象,按随机数字表法分为他克莫司组、曲安奈德组与对照组,每组20例。他克莫司组、曲安奈德组在接受规范治疗基础上分别局部外用0.1%他克莫司及0.1%曲安奈德软膏治疗6周,观察疗效及不良反应,停药4周后观察复发率。结果 他克莫司组患者总有效率为90.00%,曲安奈德组患者有效率为55.00%,对照组患者有效率为10.00%,3组患者疗效比较,差异具有统计学意义(P<0.001)。他克莫司组、曲安奈德组患者的无效率均低于对照组,且他克莫司组的无效率低于曲安奈德组,差异有统计学意义(P'< 0.0167)。治疗期间,他克莫司组1例患者,曲安奈德组2例患者出现不良反应,停药4周后,他克莫司组1例复发,曲安奈德组2例复发,两组不良反应发生率和复发率差异无统计学意义(P>0.05)。结论 他克莫司较曲安奈德对OLP患者口腔黏膜有更好的治疗效果。 |
| 英文摘要: |
| Objective To evaluate the clinical efficacy of tacrolimus ointment and triamcinolone acetonide ointment on patients with oral lichen planus (OLP).Methods These 60 OLP patients who came to the Department of Stomatology of the First Affiliated Hospital of Anhui Medical University from June 2019 to December 2019 were randomly divided into three groups according to the random number table method: Tacrolimus group (20 cases), triamcinolone acetonide group (20 cases) and control group (20 cases). The tacrolimus group was treated with 0.1% tacrolimus ointment for six weeks, and the triamcinolone acetonide group was treated with 0.1% triamcinolone acetonide ointment for six weeks. The curative effect and adverse reactions were observed. The recurrence rate was observed after four weeks of drug withdrawal in the three groups.Results The total effective rate was 90.00% in tacrolimus group, 55.00% in triamcinolone acetonide group and 10.00% in control group. There was significant difference among the three groups (P<0.001). The ineffective rates of tacrolimus and triamcinolone acetonide were lower than those of the control group, the ineffective rate of tacrolimus group was lower than that of triamcinolone acetonide group, and the difference was statistically significant(P'<0.0167).During the treatment one case in tacrolimus group and two cases in triamcinolone acetonide group had adverse reactions.After four weeks follow-up period, one case recurred in tacrolimus group and two cases relapsed in triamcinolone acetonide group.There was no significant difference in the incidence of adverse reactions and recurrence between the two groups (P>0.05).Conclusion Compared with triamcinolone acetonide, 0.1% tacrolimus is more effective in alleviating OLP symptoms and signs. |
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