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| 红细胞分布宽度与腹膜透析相关性腹膜炎的相关性 |
| Relationship between red blood cell distribution width and peritoneal dialysis-associated peritonitis |
| 投稿时间：2022-01-05 |
| DOI：10.3969/j.issn.1000-0399.2022.07.005 |
| 中文关键词: 红细胞分布宽度 腹膜透析 腹膜透析相关性腹膜炎 |
| 英文关键词: Red blood cell distribution width Peritoneal dialysis Peritoneal dialysis-associated peritonitis |
| 基金项目:四川省科技厅资助项目(项目编号:LY-448) |
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| 中文摘要: |
| 目的 探讨红细胞分布宽度(RDW)与腹膜透析相关性腹膜炎(PDAP)的相关性。方法 回顾性分析西南医科大学附属医院2016年1月至2021年7月登记管理的100例腹膜透析(PD)患者临床资料。根据RDW中位数水平分为高RDW组(RDW≥13.6%)和低RDW组(RDW<13.6%),比较两组患者一般资料(年龄、透析龄、性别、原发病、身体质量指数、是合并高血压或糖尿病、随访期间是否出现PDAP)、实验室指标(残余肾功能、血尿酸、超敏C反应蛋白、白细胞、血小板、血红蛋白、血清清蛋白、前清蛋白、校正血钙、血磷、血镁、血钾、血清铁、铁蛋白、三酰甘油、胆固醇、RDW);采用logistic回归模型分析PD患者发生PDAP的危险因素;采用Kaplan-Meier法绘制生存曲线,Log-Rank检验比较组间生存差异;采用受试者工作特征(ROC)曲线评估RDW对PDAP发生的预测价值。结果 多因素logistic回归分析显示,高水平RDW是PDAP发生的独立危险因素(OR=2.665,95%CI:1.478～4.807,P＜0.001);Kaplan-Meier曲线分析结果提示,高RDW组发生PDAP的生存时间明显短于低RDW组(Log Rank=3.969,P＜0.05);ROC曲线结果显示,RDW预测PD患者发生PDAP的曲线下面积为0.73(P＜0.05),最大约登指数为0.41,RDW最佳截断值为14.55%,其灵敏度和特异度分别为50%和91%。结论 红细胞分布宽度与腹膜透析相关性腹膜炎发生风险相关,对腹膜透析相关性腹膜炎的发生有较高的预测价值。 |
| 英文摘要: |
| Objective To investigate the correlation between red blood cell distribution width (RDW) and peritoneal dialysis-associated peritonitis (PDAP). Methods The clinical data of 100 patients with peritoneal dialysis (PD) enrolled in the Affiliated Hospital of Southwest Medical University from January 2016 to July 2021 were retrospectively analyzed. It was divided into high(RDW≥13.6%) and low RDW(RDW＜13.6%) groups according to the median RDW level. The two groups were compared in terms of general information (age, dialysis age, sex, the primary disease, body mass index, hypertension or diabetes, whether PDAP occuredduring the follow-up period), laboratory indexes (residual renal function, blood uric acid, hypersensitive c-reactive protein, white blood cells, platelets, hemoglobin, serum albumin, prealbumin, correction of blood calcium,phosphorus, magnesium, potassium, serum iron, ferritin, triacylglycerol, cholesterol, RDW). Logistic regression model was used to analyze the risk factors of PDAP in PD patients. Kaplan-meier method was used to draw the survival curve, and log-rank test was used to compare the survival differences between groups. ROC curve was used to evaluate the predictive value of RDW on PDAP occurrence. Results Multivariate logistic regression analysis showed that high level of RDW was an independent risk factor for PDAP occurrence (OR=2.665,95%CI:1.478~4.807, P<0.001). Kaplan-meier curve analysis showed that the survival time of PDAP in high RDW group was significantly shorter than that in low RDW group, and the difference was statistically significant (Log Rank=3.969, P<0.05). The receiver operating characteristic curve (ROC) curve showed that the area under the curve of RDW predicting the occurrence of PDAP in PD patients was 0.73 (P<0.05), and the maximum approximate index was 0.41. The best cut-off value of RDW was 14.55%, and its sensitivity and specificity was 50% and 91%, respectively. Conclusions Red blood cell distribution width is correlated with the risk of peritonitis associated with peritoneal dialysis-associated peritonitis, which has a high predictive value. |
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