文章摘要
儿童青少年精神分裂症患者联合用药合理性及其影响因素
Investigation on rationality of combined medication in children and adolescents with schizophrenia and analysis of its influencing factors
投稿时间:2022-03-16  
DOI:10.3969/j.issn.1000-0399.2022.10.003
中文关键词: 儿童青少年  精神分裂症  抗精神病药  用药合理性  影响因素
英文关键词: Children and adolescents  Schizophrenia  Antipsychotics  Rationality of drug use  Influencing factors
基金项目:2021年度安徽省卫生健康委科研项目(项目编号:AHWJ2021a044)
作者单位
赵永华 234000 安徽宿州 宿州市第二人民医院三病区 
刘音 234000 安徽宿州 宿州市第二人民医院三病区 
陈长浩 234000 安徽宿州 宿州市第二人民医院三病区 
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中文摘要:
      目的 调查儿童青少年精神分裂症患者联合用药的合理性,并分析其影响因素。方法 回顾性纳入2017年5月至2019年5月宿州市第二人民医院收治的120例儿童青少年精神分裂症患者,按照是否联合用药分为单一用药组(n=64)与联合用药组(n=56);以联合药物治疗疗效、适应症及不良反应(安全性)发生情况评判药物联用合理性;采用logistic回归方程分析主治医生选用联合用药及风险联用的影响因素。结果 120例患者中联合用药56例(46.67%),合理联用8例(14.29%),不合理联用27例(48.21%),风险联用21例(37.50%);logistic回归分析显示始发年龄(OR=0.482,95%CI:0.311~0.896)、住院次数(OR=1.295,95%CI:1.085~1.583)、住院天数(OR=1.137,95%CI:1.022~1.279)是主治医生选用联合用药的影响因素(P<0.05);始发年龄(OR=0.031)、住院次数(OR=1.597)、住院天数(OR=1.867)是不合理联用的影响因素(P<0.05);始发年龄(OR=0.046)、住院次数(OR=1.294)、住院天数(OR=1.217)、苯二氮卓类药物(OR=1.123)是风险联用的影响因素(P<0.05)。结论 儿童青少年精神分裂症患者联合用药的比例较高,合理联用处低水平。其中始发年龄、住院次数、住院天数是不合理联用的影响因素,始发年龄、住院次数、住院天数、苯二氮卓类药物是风险联用的影响因素。
英文摘要:
      Objective To investigate the rationality of combined medication in children and adolescents with schizophrenia, and to analyze its influencing factors. Methods A total of 120 children and adolescents with schizophrenia who were admitted to the Second People’s Hospital of Suzhou City from May 2017 to May 2019 were retrospectively selected and divided into single drug group(n=64) and combined drug group (n=56)according to whether or not with use of combined drug.The rationality of the drug combination was judged by the therapeutic efficacy, indications and adverse reactions (safety) of the combination drug.Logistic regression equation was used to analyze the influencing factors of the attending physicians’ choice of the combination drug and the risk combination. Results Among the 120 patients, 56 cases (46.67%) received combined medication,with 8 cases (14.29%) of reasonable combination, 27 cases (48.21%) of unreasonable combination, and 21 cases (37.50%) of risk combination. Logistic regression analysis showed that the age of onset (OR=0.482, 95%CI: 0.311~0.896), the number of hospitalizations (OR=1.295, 95%CI: 1.085~1.583), and the days of hospitalization (OR=1.137, 95%CI: 1.022~1.279) were the attending physicians’influencing factors of combined drug use in health care (P<0.05); age of onset (OR=0.031), hospitalization times (OR=1.597), and hospitalization days (OR=1.867) were the influencing factors for unreasonable combination therapy (P<0.05) ; Onset age (OR=0.046), number of hospitalizations (OR=1.294), length of hospital stay (OR=1.217), and benzodiazepines (OR=1.123) were the influencing factors of risk combination (P<0.05). Conclusions The proportion of combined drug use in children and adolescents with schizophrenia is high, but the level of reasonable combined use is low. Among them, the age of onset, the number of hospitalizations, and the number of days of hospitalization are the influencing factors for unreasonable combined use.
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