文章摘要
多囊卵巢综合征患抑郁症影响因素分析
Analysis of related risk factors of depression in patients with polycystic ovary syndrome
投稿时间:2021-12-07  
DOI:10.3969/j.issn.1000-0399.2022.10.004
中文关键词: 多囊卵巢综合征  抑郁症  危险因素
英文关键词: Polycystic ovary syndrome  Depression  Risk factors
基金项目:开封市科技发展计划项目(项目编号:1903003,1903108)
作者单位E-mail
陈晨 475000 河南开封 开封市中心医院妇产科  
李春红 475000 河南开封 开封市中心医院妇产科  
申凤乾 475000 河南开封 开封市中心医院肿瘤科  
李宁 475000 河南开封 开封市中心医院肿瘤科  
张超鑫 475000 河南开封 开封市中心医院医学影像科  
秦林茂 475000 河南开封 开封市第五人民医院精神科九病区  
宋莉 475000 河南开封 开封市中心医院妇产科 songli13839989862@163.com 
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中文摘要:
      目的 旨在探讨多囊卵巢综合征(PCOS)患者发生抑郁症相关影响因素。方法 选择2017年1月至2020年12月开封市中心医院232例PCOS患者,采用抑郁症症状快速自评量表(QIDS-SR16)进行抑郁状态评估,根据患者QIDS-SR16评分,≥6分为抑郁组(n=72),<6分为非抑郁组(n=160),比较两组患者一般资料、血糖、血脂和激素水平之间的差异,并行多因素logistic回归进行危险因素分析。结果 232 例PCOS患者有72例(31 %)出现抑郁症;两组患者年龄、身体质量指数(BMI)、多毛、痤疮比例和总胆固醇、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、催乳素(PRL)水平差异有统计学意义(P均<0.05);两组患者心理疾病家族史、月经量、不孕、抽烟、饮酒和睡眠障碍比例和空腹血糖、餐后2 h血糖、空腹胰岛素、硫酸脱氢表雄酮、总胆固醇、硫酸脱氢表雄酮、睾酮、雄烯二酮、性激素结合球蛋白、游离雄激素指数、孕酮、促黄体生成素、促卵泡生成素水平差异无统计学意义(P>0.05);多因素logistic 回归分析发现PCOS患者抑郁症发生的危险因素包括BMI≥25 kg/m2 (OR=3.516, 95%CI: 1.442~8.574)、LDL(OR=3.238, 95%CI: 1.883~5.570)和PRL(OR=1.362, 95%CI: 1.218~1.524);降低抑郁发生危险因素为HDL(OR=0.049, 95%CI: 0.009~0.270)。结论 高 BMI、LDL、PRL和低HDL水平是PCOS 患者并发抑郁的危险因素。
英文摘要:
      Objective The purpose of our study was to investigate the risk factors related to depression in patients with polycystic ovary syndrome (PCOS). Methods 232 PCOS patients in Kaifeng central hospital from January 2017 to December 2020 were enrolled, and quick inventory of depressive symptomatology-self report 16 item (QIDS-SR16) was used to evaluate the depression status, and the patients with QIDS-SR16 score ≥ 6 were classified as depression group, and those with QIDS-SR16 score less than 6 were classified as non-depressed group. The general information, blood glucose, blood lipids and hormone levels between the depression group (n=72) and the non-depression group (n=160) were analyzed and the multivariate logistic regression analysis was performed for risk factor analysis. Results Depression occurred in 72 (31 %) of 232 PCOS patients. There were statistical differences (all P values <0.05) between depression and non-depression group with PCOS of the the age range, body mass index (BMI), and the proportion for hirsutism and acne. There were statistical differences (all P values <0.05) between depression and non-depression group with PCOS of the levels for total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and prolactin (PRL). There were no statistical differences between depression and non-depression group with PCOS of the family history for mentally psychological illness, menstrual volume and the proportion for infertility, smoking, drinking and sleep disorder. There were no statistical differences between depression and non-depression group with PCOS of the levels for fasting plasma glucose (FPG), 2 hour postprandial blood glucose (2 h PPG), fasting serum insulin (FINS), homeostatic model assessment insulin resistance (HOMA-IR), triglycerides (TG), dehydroepiandrosterone sulfate, (DHEAS), testosterone (TE), androstenedione (ASD), sex hormone-binding globulin (SHBG), free androgen index (FAI), progesterone (PRG), luteotropic hormone (LH) and follicle-stimulating hormone (FSH). Multivariate logistic regression analysis found that the risk factors for depression in PCOS patients included BMI≥25 kg/m2 (OR: 3.516, 95%CI: 1.442~8.574), LDL (OR: 3.238, 95%CI: 1.883~5.570) and PRL (OR:1.362, 95%CI: 1.218~1.524); the risk factor hindering depression is HDL (OR: 0.049, 95%CI: 0.009~0.270). Conclusion The high BMI, LDL, PRL and low HDL levels are the risk factors for the onset of depression in patients with PCOS.
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