| Objective Explore differences between gestational diabetic offspring and normal gestational offspring at age of 3 years in physical development and insulin resistance. Methods Mothers delivered in Linquan Hospital of Anhui Maternal and Child Health Hospital in January to December 2018 who met the inclusion criteria and willing to join the study were selected, 149 pairs in GDM group and 385 pairs in normal control group were included. In January to December 2021，physical measurement and blood were collected, and maternal height, pregestational weight, prenatal weight, prenatal pregnancy, birth history, offspring birth related data and other data were filled into questionnaire. Differences in physical development and insulin resistance of progeny at age of 3 years were compared between GDM and normal control group, according to the weight of children, the relevant data were compared and analyzed between normal weight group and overweight or obese group.Results Compared with the normal control group, maternal reproductive age, pregestational BMI, overweight or obesity proportion were higher, and offspring birth weight, overweight or obesity proportion were higher in GDM group (all P< 0.05). Children who were overweight or obese at 3 years old had higher birth weight, comparing with normal weight children (P< 0.05), and regression analysis showed that pregestational obesity (OR= 2.581,95%CI: 1.199~5.557, P=0.015), GDM during pregnancy (OR= 2.309,95%CI: 1.296~4.115, P=0.005) were risk factors for overweight or obesity. No significant difference in insulin resistance between GDM and normal control group was found (P>0.05). Conclusion GDM and pre-pregnancy obesity increase the risk of overweight or obesity in 3-year-old children, however, no increased risk of insulin resistance was shown. |
