| Objective To investigate the effect of body mass index (BMI)on the pregnancy outcome of preimplantation aneuploidy genetic test (PGT-A) in patients with recurrent spontaneousabortion （RSA） . Methods The clinical data of 187 patients who underwent PGT-A due to recurrent abortion in the First Affiliated Hospital of Anhui Medical University from January 2019 to December 2020 were analyzed retrospectively. The patients were divided into low body mass index group (n=10), normalbody mass index group (n=135) and overweight group (n=42) according to their BMI. The laboratory indicators of different BMI patients were compared, including(number of oocytes obtained, number of two pronucleicleavage, total gonadotropin (Gn) days, aneuploid embryo rate and non-transferable embryo rate), and embryo transfer outcome (clinical pregnancy rate, flow rate and live rate) were compared among the three groups. Results There was no significant difference in the number of oocytes obtained, the number of two pronucleicleavage, the total number of Gn days, the rate of aneuploid embryos and the rate of non-transferable embryos among the three groups (F =1.819、 2.012、 2.467, χ2=0.924, 0.040, P＞0.05）. After the first transfer of an aneuploid embryo, the clinical pregnancy rate and live birth rate of the overweight patients were lower than those of the normal body mass index patients (χ2=5.934、 9.977， P＜0.05); there was no significant difference in the abortion rate among the three groups (χ2=4.755, P＞0.05). Conclusions The increase of body mass index does not lead to the increase of aneuploid embryo rate in patients with recurrent abortion, but may reduce the clinical pregnancy rate and live birth rate of patients. |
