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| 有氧运动改善慢性阻塞性肺疾病大鼠肺功能的机制分析 |
| Mechanism analysis of aerobic exercise improving pulmonary function in rats with chronic obstructive pulmonary disease |
| 投稿时间：2022-11-15 |
| DOI：10.3969/j.issn.1000-0399.2023.10.005 |
| 中文关键词: 有氧运动 慢性阻塞性肺疾病 肺功能 炎症反应 信号通路 |
| 英文关键词: Aerobic exercise Chronic obstructive pulmonary disease Lung function Inflammatory response Signaling pathway |
| 基金项目:河南省医学科技攻关项目（编号：LHGJ20190867） |
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| 中文摘要: |
| 目的 探讨有氧运动通过影响肺部炎症调控慢性阻塞性肺疾病（COPD）大鼠肺功能的机制。方法 建立COPD大鼠模型并分为对照组和运动组。运动组进行9周跑台运动；对照组不干预。检测两组大鼠第1秒用力呼气量（FEV1）、用力呼气量（FVC）、最大呼气中段流速（MMEF）、呼气峰流速（PEF）。处死大鼠进行HE染色，采用Western blot法检测肺组织的趋化素（CHEM）、趋化因子受体-1（CMKLR1）、白细胞介素（IL）-1β、IL-6、IL-8、肿瘤坏死因子（TNF）-α蛋白表达水平。结果 运动组大鼠MMEF、PEF高于对照组（P<0.05）；两组大鼠FEV1、FVC水平接近（P>0.05）。运动组大鼠肺组织CHEM、IL-1β、IL-8蛋白表达高于对照组，CMKLR1低于对照组（P<0.05）；两组肺组织IL-6、TNF-α蛋白表达接近（P>0.05）。结论 有氧运动可改善COPD大鼠肺功能及肺组织病理损害，且这一作用与有氧运动对炎症的抑制作用有关。 |
| 英文摘要: |
| Objective To explore the mechanism of aerobic exercise regulating lung function in chronic obstructive pulmonary disease(COPD) rats through its effect on pulmonary inflammation. Methods The COPD rat model was established and divided into control group and exercise group. The exercise group ran the table for nine weeks. The control group received no intervention. Forced expiratory volume in one second(FEV1), forced expiratory volume(FVC), maximum mid-expiratory flow rate(MMEF) and peak expiratory flow rate(PEF) of the two groups were detected. The rats were sacrificed for HE staining, and the expression levels of chemokine(CHEM), chemokine receptor-1(CMKLR1), interleukin(IL)-1β, IL-6, IL-8 and tumor necrosis factor(TNF)-α in lung tissues were detected by Western blot. Results The MMEF and PEF in the exercise group were higher than those in the control group(P<0.05). The levels of FEV1 and FVC in the two groups were close(P>0.05). The expression of CHEM, IL-1β and IL-8 protein in lung tissue of the exercise group was higher than that of the control group, and CMKLR1 was lower than that of the control group(P<0.05). The expressions of IL-6 and TNF-α in lung tissue were similar between the two groups(P>0.05).Conclusion The aerobic exercise can improve lung function and pathological damage of lung tissue in COPD rats, and this effect is related to the inhibitory effect of aerobic exercise on inflammation. |
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