| Objective To investigate the application value of systemic inflammatory response index(SIRI) and systemic immune inflammatory index(SII) in the assessment of disease activity in patients with ulcerative colitis.Methods A total of 190 patients with ulcerative colitis(UC) and 79 healthy volunteers admitted to the Department of Gastroenterology of Anhui Provincial Hospital from December 2020 to December 2022 were included in this study. The patients with UC were divided into three groups, namely, mild active group, moderate active group and severe active group according to Mayo score. Seventy-nine healthy volunteers were selected as the healthy control group, then relevant test indexes of all UC patients during hospitalization and blood routine results of healthy volunteers were collected, and SIRI, SII and neutrophil to lymphocyte ratio(NLR) results of the four groups were compared.Results Compared with healthy control group, SIRI, SII and NLR were raised in UC patients, and the difference was statistically significant(P<0.05). The comparison between mild, moderate and severe UC patients showed that the levels of SIRI, SII and NLR in severe UC patients were higher than those in moderate and mild UC patients, and the difference was statistically significant(P<0.05); the levels of SIRI, SII, NLR in moderate UC patients were higher than those in mild UC patients, and the difference was statistically significant(P<0.05). In all UC patients, SII, SIRI and NLR were positively correlated with the expression levels of ESR and CRP(P<0.05), and negatively correlated with the expression levels of albumin(P<0.05). Meanwhile, SII was negatively correlated with the expression levels of hemoglobin(P<0.05). ROC curve analysis showed that the diagnostic efficacy of SII was greater than that of SIRI and NLR in patients with moderate and severe UC compared with those mild active UC(P<0.05), and there was no statistical difference compared with the combined diagnostic efficacy of the indexes(P>0.05).Conclusions SII and SIRI are related to disease activity in UC patients, and have good discriminability for patients with different disease activity, and SII is better than SIRI in predicting value. |
