|
| 肺癌患者血清癌胚抗原干扰素-γ白细胞介素-8水平及预后价值 |
| The value of combined detection of serum carcinoembryonic antigen, interferon, and interleukin-8 in predicting the prognosis of lung cancer |
| 投稿时间：2023-06-14 |
| DOI：10.3969/j.issn.1000-0399.2024.03.009 |
| 中文关键词: 肺癌 癌胚抗原 干扰素-γ 白细胞介素-8 |
| 英文关键词: Lung cancer Carcinoembryonic antigen Interferon-γ Interleukin-8 |
| 基金项目: |
|
| 摘要点击次数: 58 |
| 全文下载次数: 42 |
| 中文摘要: |
| 目的 探究血清癌胚抗原（CEA）、干扰素-γ（IFN-γ）、白细胞介素-8（IL-8）联合检测在肺癌预后判断中的价值。方法 选取2016年1月至2018年1月在上海市宝山区仁和医院收治的80例肺癌患者作为研究对象，另外选取同期在我院检查健康的80名健康体检者为对照组，比较两组对象血清CEA、IFN-γ、IL-8水平；对不同分期、不同病理类型和不同预后的肺癌患者血清CEA、IFN-γ、IL-8水平进行比较；所有患者随访5年，记录其生存情况，根据患者预后分为预后良好组（56例）和预后不良组（24例）；比较不同血清CEA、IFN-γ、IL-8水平患者的5年生存率。受试者工作特征（ROC）曲线分析血清CEA、IFN-γ、IL-8对肺癌患者不良预后的预测价值。比较肺癌患者治疗前后血清CEA、IFN-γ、IL-8水平变化。结果 肺癌组血清CEA、IL-8水平高于对照组，IFN-γ水平低于对照组，差异有统计学意义（P＜0.05）。与TNM分期Ⅲ期患者比较，TNM分期Ⅳ期患者血清CEA、IL-8水平升高，IFN-γ水平降低，差异有统计学意义（P＜0.05）。与CEA高水平患者相比，CEA低水平患者5年生存率较高；与IFN-γ高水平患者相比，IFN-γ低水平患者5年生存率较低；与IL-8高水平患者相比，IL-8低水平患者5年生存率较高。血清CEA、IFN-γ、IL-8评估肺癌患者不良预后的曲线下面积（AUC）分别是0.817（95% CI：0.713~0.921）、0.818（95% CI：0.727~0.910）、0.781（95% CI：0.654~0.907），三者联合检测的AUC为0.917（95% CI：0.843~0.990）。与预后良好组相比，预后不良组血清CEA、IL-8水平升高，IFN-γ水平降低（P＜0.05）。治疗后血清CEA、IL-8水平比治疗前低，IFN-γ水平比治疗前高，差异有统计学意义（P＜0.05）。结论 肺癌患者血清CEA、IL-8水平升高，IFN-γ水平降低，且与患者预后相关，可作为预测肺癌患者预后不良的评估指标。 |
| 英文摘要: |
| Objective To explore the value of the combination of serum carcinoembryonic antigen (CEA), interferon-γ (IFN-γ), and interleukin-8 (IL-8) in the prognosis of lung cancer. Methods Eighty lung cancer patients admitted to Renhe Hospital of Baoshan District, Shanghai from January 2016 to August 2018 were collected as the study subjects; in addition, 80 healthy physical examination who underwent health checks in our hospital were collected as the control group, then the serum levels of CEA, IFN-γ, and IL-8 were compared between the two groups.The serum levels of CEA, IFN-γ, and IL-8 were compared among lung cancer patients with different stages, pathological types, and prognosis. The patients were followed up for five years, and their survival was recorded. The patients were divided into good prognosis group (56cases) and poor prognosis group (24 cases).The prognostic survival rates of lung cancer patients with different serum CEA, IFN-γ and IL-8 levels were compared. ROC curve was applied to analyze the predictive value of serum CEA, IFN-γ, and IL-8 for poor prognosis in lung cancer patients. Paired sample t-test was applied to compare changes in serum CEA, IFN-γ, and IL-8 levels in lung cancer patients before and after treatment. Results The serum CEA and IL-8 levels in the lung cancer group were higher than those in the control group, while the IFN-γ level was lower than that in the control group (P<0.05). Compared with TNMIII patients, the serum levels of CEA and IL-8 in TNM IV patients increased, while IFN-γ level decreased (P<0.05). The 5-year survival rate of patients with low CEA level was higher than that of patients with high CEA level; The 5-year survival rate of patients with low IFN-γ level was lower than that of patients with high IFN-γ level; The 5-year survival rate of patients with low level of IL-8 was higher than that of patients with high level of IL-8. The area under the curve (AUC) of serum CEA, IFN-γ, and IL-8 for evaluating poor prognosis in lung cancer patients was 0.817 (95% CI: 0.713~0.921), 0.818 (95% CI: 0.727~0.910), and 0.781 (95% CI: 0.654~0.907), respectively, and the AUC of the three combined tests was 0.917 (95% CI: 0.843~0.990). Compared with the group with good prognosis, the group with poor prognosis showed an increase in serum CEA and IL-8 levels and a decrease in IFN-γ level (P<0.05). After treatment, the serum levels of CEA and IL-8 were lower than those before treatment, while the IFN-γ level was higher than that before treatment (P <0.05). Conclusions Serum CEA and IL-8 levels increase in lung cancer patients, while IFN-γ levels decrease. They are related to prognosis of patients and can be used an evaluation indicators for predicting poor prognosis in lung cancer patients. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
