| Objective To explore the diagnostic value of serum vasohibin-1 (VASH-1), fibroblast growth factor-23 (FGF23) and urinary β2-microglobulin (β2-MG) in diabetes nephropathy (DN). Methods A total of 115 patients with DN who underwent treatment at the Central Hospital of Jiaozuo Coal Industry (Group) Co Ltd from January 2022 to May 2023 were selected as the DN group, and 60 healthy examinees from our hospital were regarded as the control group. The DN group was separated into normal albuminuria group (A group, 35 cases), microalbuminuria group (B group, 41 cases), and macroalbuminuria group (C group, 39 cases) based on 24-hour urinary albumin excretion rate (URER). The levels of serum VASH-1 and FGF-23 levels, urea, creatinine levels, and urinary β2-MG levels were compared; Pearson method was applied to analyze the correlation between serum VASH-1, FGF-23 levels, urea, creatinine levels, and urinary β2-MG level; multivariate logistic regression was applied to analyze the influencing factors of DN occurrence; receiver operating characteristic (ROC) curve was applied to analyze the diagnostic value of serum VASH-1, FGF-23 combined with urine β2-MG for DN. Results The levels of serum VASH-1, FGF- 23, urea, creatinine levels, and urine β2-MG in the DN group were obviously higher than those in the control group (P<0.05); the levels of serum VASH-1, FGF-23 levels, urea, creatinine levels, and urinary β2-MG in group C were obviously higher than those in group B and group A (P<0.05); the levels of serum VASH-1 and FGF-23 in DN patients were positively correlated with urea, creatinine, and urinary β2-MG (P<0.05); the levels of serum VASH-1, FGF-23 levels, urea, creatinine, and urine β2-MG were risk factors for DN (P<0.05); the combined diagnostic value of serum VASH-1, FGF-23, and urinary β2-M for DN was higher than that of individual diagnosis (Zthree combination-VASH-1=4.389, P<0.001, Zthree combination-FGF-23=3.117, P=0.002, Zthree combination-β2-MG=4.556, P<0.001). Conclusion The serum VASH-1, FGF-23, and urine β2-MG levels in DN patients are related to the occurrence and development of disease, and the combined diagnosis of the three is effective, which is expected to provide certain clinical diagnostic value for the diagnosis of DN. |
