文章摘要
血清血管生成抑制蛋白-1成纤维生长因子-23联合尿β2-微球蛋白对DN的诊断价值
The diagnostic value of serum vasohibin-1 fibroblast growth factor-23 combined with urinary β2-microglobulin for diabetes nephropathy
投稿时间:2023-09-13  
DOI:10.3969/j.issn.1000-0399.2024.05.004
中文关键词: 糖尿病肾病  血管生成抑制蛋白-1  成纤维生长因子-23  β2-微球蛋白
英文关键词: Diabetic nephropathy  Vasohibin-1  Fibroblast growth factor-23  β2-microglobulin
基金项目:河南省医学科技攻关项目(编号:LHGJ2020021837)
作者单位
胡伟宏 454000 河南焦作 焦作煤业(集团)有限责任公司中央医院检验科 
陈文洁 454000 河南焦作 焦作煤业(集团)有限责任公司中央医院检验科 
赵丽萍 454000 河南焦作 焦作煤业(集团)有限责任公司中央医院检验科 
张亚琦 454000 河南焦作 焦作煤业(集团)有限责任公司中央医院检验科 
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中文摘要:
      目的 探究血清血管生成抑制蛋白-1(VASH-1)、成纤维生长因子-23(FGF23)联合尿 β2-微球蛋白(β2-MG)对糖尿病肾病(DN)的诊断价值。 方法 选取 2022 年 1 月至 2023 年 5 月在焦作煤业(集团)有限责任公司中央医院进行治疗的 115 例 DN 患者作为 DN 组,选取同时期本院 60 例健康体检者为对照组。根据 24 h 尿清蛋白排泄率(URER),将 DN 组分为单纯糖尿病组(A 组,35例)、微量清蛋白尿组(B 组,41 例)和大量清蛋白尿组(C 组,39 例);比较受试者血清 VASH-1、FGF-23 水平、尿素、肌酐含量、尿 β2-MG水平;采用 Pearson 法对血清 VASH-1、FGF-23 水平与尿素、肌酐含量、尿 β2-MG 水平进行相关性分析;采用多因素 logistic 回归分析DN 发生的影响因素;受试者工作特征(ROC)曲线分析血清 VASH-1、FGF-23 联合尿 β2-MG 对 DN 的诊断价值。 结果 DN 组血清VASH-1、FGF-23、尿素、肌酐含量、尿 β2-MG 水平均高于对照组(P<0.05);C 组患者血清 VASH-1、FGF-23、尿素、肌酐含量、尿 β2-MG 水平均高于 B 组和 A 组(P<0.05);DN 患者血清 VASH-1、FGF-23 水平与尿素、肌酐含量、尿 β2-MG 水平均呈正相关(P<0.05);血清VASH-1、FGF-23、尿素、肌酐含量、尿 β2-MG 水平均为影响 DN 发生的危险因素(P<0.05);血清 VASH-1、FGF-23、尿 β2-M 联合诊断DN 价值高于单独诊断(Z三者联合-VASH-1=4.389、P<0.001,Z三者联合-FGF-23=3.117、P=0.002,Z三者联合-β2-MG=4.556、P<0.001)。 结论 DN 患者血清VASH-1、FGF-23、尿 β2-MG 水平与疾病的发生发展有关,且三者联合诊断效果较好,有望为 DN 的诊断提供一定的临床诊断价值。
英文摘要:
      Objective To explore the diagnostic value of serum vasohibin-1 (VASH-1), fibroblast growth factor-23 (FGF23) and urinary β2-microglobulin (β2-MG) in diabetes nephropathy (DN). Methods A total of 115 patients with DN who underwent treatment at the Central Hospital of Jiaozuo Coal Industry (Group) Co Ltd from January 2022 to May 2023 were selected as the DN group, and 60 healthy examinees from our hospital were regarded as the control group. The DN group was separated into normal albuminuria group (A group, 35 cases), microalbuminuria group (B group, 41 cases), and macroalbuminuria group (C group, 39 cases) based on 24-hour urinary albumin excretion rate (URER). The levels of serum VASH-1 and FGF-23 levels, urea, creatinine levels, and urinary β2-MG levels were compared; Pearson method was applied to analyze the correlation between serum VASH-1, FGF-23 levels, urea, creatinine levels, and urinary β2-MG level; multivariate logistic regression was applied to analyze the influencing factors of DN occurrence; receiver operating characteristic (ROC) curve was applied to analyze the diagnostic value of serum VASH-1, FGF-23 combined with urine β2-MG for DN. Results The levels of serum VASH-1, FGF- 23, urea, creatinine levels, and urine β2-MG in the DN group were obviously higher than those in the control group (P<0.05); the levels of serum VASH-1, FGF-23 levels, urea, creatinine levels, and urinary β2-MG in group C were obviously higher than those in group B and group A (P<0.05); the levels of serum VASH-1 and FGF-23 in DN patients were positively correlated with urea, creatinine, and urinary β2-MG (P<0.05); the levels of serum VASH-1, FGF-23 levels, urea, creatinine, and urine β2-MG were risk factors for DN (P<0.05); the combined diagnostic value of serum VASH-1, FGF-23, and urinary β2-M for DN was higher than that of individual diagnosis (Zthree combination-VASH-1=4.389, P<0.001, Zthree combination-FGF-23=3.117, P=0.002, Zthree combination-β2-MG=4.556, P<0.001). Conclusion The serum VASH-1, FGF-23, and urine β2-MG levels in DN patients are related to the occurrence and development of disease, and the combined diagnosis of the three is effective, which is expected to provide certain clinical diagnostic value for the diagnosis of DN.
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