| Objective To explore the correlation between social avoidance and multi-cognitive dysfunctions in patients with advanced Parkinson’s disease. Methods From March 2023 to December 2023, 58 patients with advanced Parkinson’s disease from the Department of Neurology, the First Affiliated Hospital of Anhui Medical University, were involved.The scores of social avoidance scale and distress scale were performed. All participants were divided into the PD group with social avoidance and distress (SAD group, n=29 cases) and the PD group without social avoidance and distress (NSAD group, n=29 cases) according to the social avoidance and distress scale. The cognitive functions of all subjects was assessed using the Mini-mental State Examination (MMSE), Auditory Verbal Learning Test (AVLT), Digital Span Test (DST), Trail Making Test A (TMA), Test B (TMB), Frontal Assessment Battery (FAB), Category Verbal Fluency(CVF) and Phonemic Verbal Fluency (PVF). The differences in MMSE, AVLT, DST, TMA, TMB, FAB, CVF and PVF between SAD group and NSAD group were compared respectively. The Spearman rank correlation analysis of cognitive function scores with scores of social avoidance and distress scale was conducted subsequently. The multiple linear regression was conducted to explore risk factors for recognitive impairments. Results The scores of MMSE, DST reverse order, TMA, TMB and FAB of the SAD group were significantly worse than those of the NSAD group (P<0.05). The Spearman correlation analysis further showed that the score of social avoidance and distress scale had negative correlation with scores of MMSE, AVLT-8, DST reverse and FAB (r=-0.502, -0.350, -0.542, -0.432, P<0.05), and positive correlation with TMA and TMB scores (r=0.543, 0.626,P< 0.05). Multiple linear regression found that the score of social avoidance and distress scale and years of schooling were risk factors for different fields of cognitive impairments (P<0.05). Conclusion In patients with advanced Parkinson's disease, social avoidance is associated with the decline of overall cognition, and especially with the decline of attention and executive ability. |
