文章摘要
缺氧诱导因子-1α、肾损伤因子-1在IgA血管炎患儿中的表达及其预测合并肾损伤的价值分析
Expression of hypoxia-inducible factor-1α and kidney injury molecule-1 in children with IgA vasculitis and its value in predicting kidney injury
投稿时间：2024-08-06  修订日期：2025-04-20
DOI：
中文关键词: IgA血管炎  肾损伤  缺氧诱导因子-1α  肾损伤因子-1
英文关键词: IgA vasculitis  Kidney injury  Hypoxia-inducible factor-1α  Kidney injury molecule-1
基金项目:无
作者单位邮编
李平* 河南省周口市妇幼保健院 466000
摘要点击次数: 52
全文下载次数: 0
中文摘要:
      目的 分析缺氧诱导因子-1α（HIF-1α）、肾损伤因子-1（KIM-1）在IgA血管炎（IgAV）患儿中的表达及其预测肾损伤发生的价值。方法 将2023年1月至2024年12月在我院就诊的118例IgAV患儿纳入研究，根据患儿是否合并肾损伤将其分为对照组（未合并肾损伤，n=78）和观察组（合并肾损伤，n=40）。比较两组患儿HIF-1α、KIM-1水平以及血清肌酐（Scr）、尿素氮（BUN）、尿酸（UA）水平；使用Pearson相关性分析法分析HIF-1α、KIM-1水平与Scr、BUN、UA水平的相关性；使用受试者工作特征（ROC）曲线分析HIF-1α、KIM-1水平预测患儿肾损伤发生的临床价值。结果 观察组HIF-1α、KIM-1水平以及Scr、BUN、UA水平均高于对照组（P<0.001）；Pearson相关性分析结果显示患儿HIF-1α、KIM-1水平与Scr、BUN、UA水平均呈正相关（P<0.001）；ROC曲线分析结果显示，HIF-1α水平预测患儿肾损伤发生的最佳临界值为HIF-1α≥27.80 pg/mL，此时曲线下面积为0.921（95% CI：0.855～0.987，P<0.001），灵敏度为87.50%，特异度为88.46%；KIM-1水平预测患儿肾损伤发生的最佳临界值为KIM-1≥1.85 ng/mL，此时曲线下面积为0.949（95% CI：0.897～1.000，P<0.001），灵敏度为90.00%，特异度为96.15%。结论 HIF-1α、KIM-1在IgAV伴肾损伤患儿中呈高表达，且HIF-1α、KIM-1水平与患儿肾损伤程度呈正相关，检测HIF-1α、KIM-1水平在预测患儿肾损伤发生中具有较高临床价值。
英文摘要:
      Objective To analyze the expression of hypoxia-inducible factor-1α (HIF-1α) and kidney injury molecule-1 (KIM-1) in children with IgA vasculitis (IgAV) and its value in predicting kidney injury. Methods A total of 118 children with IgAV treated in our hospital from January 2023 to December 2024 were enrolled in the study.According to the presence or absence of kidney injury, they were divided into the control group (without kidney injury, n=78) and the observation group (with kidney injury, n=40). The levels of HIF-1α, KIM-1, serum creatinine (Scr), blood urea nitrogen (BUN), and uric acid (UA) were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between HIF-1α, KIM-1 levels and Scr, BUN, UA levels. The receiver operating characteristic (ROC)curve was used to analyze the clinical value of HIF-1α and KIM-1 levels in predicting the occurrence of kidney injury in children with IgAV. Results The levels of HIF-1α, KIM-1, Scr, BUN, and UA in the observation group were all higher than those in the control group (P<0.001). Pearson correlation analysis showed that HIF-1α, KIM-1 levels were all positively correlated with Scr, BUN, and UA levels in children with IgAV (P<0.001). ROC curve analysis showed that the best critical value of HIF-1α level for predicting kidney injury in children with IgAV was HIF-1α≥27.80 pg/mL, the area under the curve at this time was 0.921 (95% CI：0.855～0.987, P<0.001), the sensitivity was 87.50%, and the specificity was 88.46%. The best critical value of KIM-1 level for predicting kidney injury in children with IgAV was KIM-1≥1.85 ng/mL, the area under the curve at this time was 0.949 (95% CI：0.897～1.000，P<0.001), the sensitivity was 90.00%, and the specificity was 96.15%. Conclusions The HIF-1α and KIM-1 are high expressed in children with IgAV with kidney injury, and the levels of HIF-1α and KIM-1 are positively correlated with the degree of kidney injury of the children with IgAV ,detection of HIF-1α and KIM-1 levels in children with IgAV has high clinical value in predicting the occurrence of kidney injury.
View Fulltext   查看/发表评论  下载PDF阅读器
关闭