| Objective To analyze the expression level difference and diagnostic efficacy of interleukin-6 (IL-6), interleukin-10 (IL- 10) and white blood cell count/lymphocyte ratio (WBC/LYM) in patients with oral and maxillofacial space infection. Methods We selected the data of 144 patients who were admitted to the Affiliated Hospital of Xuzhou Medical University due to oral and maxillofacial space infection (OMSI) from January 2019 to March 2022. At the same time, 136 patients with benign parotid tumors without inflammation were selected as the control group. IL-6, IL-10, WBC/LYM, C-reactive protein (CRP), percentage of neutrophils (NEU%), white blood cell count (WBC) were collected before treatment, and the relationship between IL-6, IL-10, WBC/LYM and the clinical characteristics of OMSI patients and diagnostic value was analyzed using single factor analysis and ROC curve. Results The levels of IL-6, IL-10 and WBC/LYM in OMSI patients were significantly higher than those in non space infection patients, and the difference was statistically significant (P＜0.05); the ROC curve results showed that the area under curve (AUC) of IL-10, IL-6, and WBC/LYM was 0.868, 0.947, and 0.942, respectively. The AUC for combined detection of five factors was 0.985, the sensitivity was 0.962, and the specificity was 0.948. Conclusion IL-10, IL-6, WBC/LYM can be combined with CRP, WBC and NEU% to diagnose OMSI efficiently and accurately. High levels of IL-6, IL-10, WBC/LYM are important reference indicators for OMSI patients to prolong hospital stay, develop complications and require ICU monitoring after surgery. |
