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| 老年T2DM伴抑郁症状患者认知功能受损相关性研究 |
| Study on the correlation of impaired cognitive function in elderly patients with T2DM with depressive symptoms |
| 投稿时间：2024-10-02 修订日期：2025-06-23 |
| DOI： |
| 中文关键词: 老年 2型糖尿病 抑郁症状 认知功能受损 |
| 英文关键词: Elderly Type 2 diabetes Depression Cognitive impairment |
| 基金项目:无 |
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| 摘要点击次数: 31 |
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| 中文摘要: |
| 目的 探究老年2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者中抑郁症状的发生率,并分析其相关性,分析老年T2DM共病抑郁症状患者认知功能受损现状,为临床干预提供参考。方法 选取2022年09月-2023年03月我院收治的200名老年2型糖尿病患者为研究对象。通过自制调查问卷,收取患者性别、年龄、BMI、糖尿病病程、糖尿病并发症数量、是否胰岛素治疗等信息,采用15项老年抑郁量表(GDS-15)进行抑郁状态的评估的评分,根据GDS评分结果将患者分为两组：非抑郁组(<5分),抑郁症状组(≥5分),；采用蒙特利尔认知评估量表(MoCA量表,Montreal Cognitive Assessment),分量表分别对两组患者进行认知障碍的评估。结论结果 本研究纳入200名老年2型糖尿病患者,依据根据抑郁情况分组,其中抑郁组112例,非无抑郁组 88例,两组多因素logistic回归结果显示,性别、BMI分组、糖化血红蛋白分组、教育年限、认知功能分组、视空间与执行功能、注意与抑郁独立相关,分析显示,差异有统计学意义(P <0.05)。依据根据认知功能受损分分组,认知功能正常组49例,认知功能受损组151例,两组教育年限、BMI分组、糖化血红蛋白分组比较与认知功能受损相关,差异有统计学意义(P <0.05)。结论 老年T2DM患者抑郁症状和认知功能受损患病率较高,性别、高BMI、高糖化血红蛋白水平、低教育程度及认知功能受损与老年T2DM患者共病抑郁症状有关。低教育程度、高BMI、高糖化血红蛋白水平与老年T2DM患者共病抑郁症状及认知功能受损呈正相关,有一定的临床指导意义。 |
| 英文摘要: |
| Objective To investigate the incidence of depressive symptoms in elderly patients with Type 2 Diabetes Mellitus (T2DM) and analyze their correlation, and to analyze the current status of impaired cognitive function in elderly patients with co-morbid depressive symptoms with T2DM, in order to provide a reference for clinical intervention. Methods 200 elderly patients with type 2 diabetes mellitus admitted to our hospital from September 2022 to March 2023 were selected as study subjects. Through a self-administered questionnaire, we collected information on patients" gender, age, BMI, duration of diabetes, diabetes complications, and whether they were on insulin therapy, and used the 15-item Geriatric Depression Scale (GDS-15) to score the assessment of depressive status, and divided the patients into two groups based on the results of the GDS scores: the non-depressed group (<5 points), and the group of depressive symptoms (≥5 points); and used the Montreal Cognitive Assessment Scale (MoCA Scale). Scale (MoCA Scale, Montreal Cognitive Assessment) to assess the cognitive impairment of patients in the two groups, respectively. Results Two hundred elderly patients with type 2 diabetes were included in this study, grouped according to depression in which there were 112 cases in the depressed group and 88 cases in the non-depressed group. The results of multifactorial logistic regression showed that the independent correlation analysis of gender, BMI grouping, glycated hemoglobin grouping, years of education, cognitive function grouping, visuospatial and executive functioning, and attention and depression showed that the differences were statistically significant (P < 0.05). According to the subgroup of impaired cognitive function, there were 49 cases in the group with normal cognitive function and 151 cases in the group with impaired cognitive function. Years of education, BMI subgroup, and glycated hemoglobin subgroup of the two groups were correlated with impaired cognitive function, and the difference was statistically significant (P < 0.05). Conclusion The prevalence of depressive symptoms and impaired cognitive function was higher in elderly T2DM patients, and gender, high BMI, high glycated hemoglobin level, low education, and impaired cognitive function were associated with co-morbid depressive symptoms in elderly T2DM patients. Low education, high BMI, and high glycated hemoglobin level were positively associated with co-morbid depressive symptoms and cognitive impairment in elderly T2DM patients, which has some clinical significance. |
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