| Objective To evaluate the value of Ovarian-Adnexal Reporting and Data System(O-RADS) combined with cancer antigen 125(CA125), human epididymis protein 4(HE4) and risk of malignancy index(RMI) in differential diagnosis of benign and malignant ovarian tumors. Methods The data of 69 patients with ovarian tumors who underwent ultrasound examination and obtained postoperative pathology in the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital) from June 2022 to June 2023 were retrospectively analyzed. According to the pathological type, the patients were divided into the benign group(n=49) and the malignant group(n=20). The differences in clinical and ultrasound characteristics between the two groups were analyzed,and the logistic multivariate regression equation was constructed to explore the risk factors of ovarian malignant tumors.With pathological results as the gold standard,receiver operating characteristic(ROC) curve was drawn to analyze the diagnostic efficacy of ultrasound O-RADS classification,CA125,HE4 and RMI alone or in combination for ovarian tumors. Results The results of univariate analysis showed that there were significant differences in serum CA125, HE4, RMI, ascites, blood flow signal, irregular inner wall and lesion diameter between the two groups(P<0.05).Multivariate analysis showed that blood flow signal was an independent risk factor for the diagnosis of malignant ovarian tumors(P<0.05).The area under the curve(AUC) for the combined diagnosis of the four [0.890 (95% CI: 0.809 to 0.971)] in diagnosing ovarian malignant tumors was superior to the AUC of O-RADS classification [0.771 (95% CI: 0.659 to 0.883)],HE4 [0.766 (95% CI: 0.634 to 0.899)],CA125 [0.709 (95% CI: 0.560 to 0.858)]andRMI [0.719 (95% CI: 0.571 to 0.868)]alone for each indicator(P<0.001). Conclusion O-RADS classification combined with CA125, HE4 and RMI can effectively improve the diagnostic value of ovarian malignant tumors. |
