| Objective To investigate the effect of modified small incision total thyroidectomy under 3D endoscopy on differentiated thyroid cancer (DTC) and its impact on inflammatory trauma indicators. Methods Eighty DTC patients admitted to Nanchong Central Hospital from July 2018 to September 2020 were selected and divided into a control group and a study group of 40 cases each according to the random number table method. The control group was given modified small-incision total thyroidectomy, and the study group was given modified Miccoli surgery under 3D lumenscopy. The two groups were compared in terms of surgical results, surgical conditions, inflammatory trauma indexes [C-reactive protein (CRP), interleukin-6 (IL-6)], thyroid function indexes [triiodothyronine (T3), thyroid hormone (T4), free triiodothyronine (FT3), free thyroid hormone (FT4)], circulating tumor cells (CTC), tumor markers [thyroid globulin (Tg), tumor-specific growth factor (TSGF), vascular endothelial growth factor (VEGF)], complication rate and 1-year postoperative recurrence rate. Results The operation duration in the study group was shorter than that in the control group, and the intraoperative blood loss was less than that in the control group (P<0.05). Both groups exhibited an upward trend followed by a downward trend in serum levels of CRP and IL-6 before surgery and on the first and third days after surgery (P<0.05). There were no statistically significant differences in preoperative serum levels of CRP, IL-6, T3, T4, FT3, and FT4 between the two groups (P>0.05). Postoperatively, serum levels of CRP, IL-6, T3, T4, FT3, and FT4 were lower in the study group on the first and third days after surgery compared to the control group (P<0.05). Within both groups, postoperative levels of CTC, serum Tg, VEGF, and TSGF on the first day were lower than those before surgery and on the first day after surgery (P<0.05). There were no statistically significant differences in preoperative and postoperative levels of CTC, serum Tg, VEGF, and TSGF between the two groups on the third day after surgery (P>0.05). The incidence of complications in the study group was lower than that in the control group (P<0.05). There were no statistically significant differences in total treatment efficacy and recurrence rate one year postoperatively between the two groups (P>0.05). Conclusion The modified minimal incision thyroidectomy under 3D endoscopy for the treatment of DTC can optimize the surgical conditions, reduce the degree of inflammatory trauma, reduce complications, and have minimal impact on the body’s thyroid function without increasing the risk of recurrence. |
