| Objective To investigate the application of sinus enlargement and opening (EESS) in chronic sinusitis (CRS) with type 2 inflammation. Methods A total of 102 patients with CRS type 2 inflammation who received EESS treatment in Tangshan People’s Hospital of Hebei province from June 2019 to June 2022 were randomly divided into two groups: the control group and the observation group. The control group (n=51) underwent middle turbinectomy during EESS, while the observation group (n=51) underwent partial middle turbinectomy during EESS. The observation group received EESS, and the middle turbinate was preserved during the operation. Inflammatory indicators [Peripheral blood eosinophils (EOS) and serum interleukin-4 (IL-4), Interleukin-5 (IL-5)], disease improvement [visual analogue score (VAS), LundKennedy, Lund-Mackay scores], nasal function [nasal volume (NCV), minimum cross-sectional area (NMCA), airway resistance, etc.], olfactory function, perioperative complications and one-year postoperative recurrence rate were compared between the two groups before and after surgery. Results The levels of EOS, IL-4 and IL-5 in the observation group were lower than those in the control group three months after opera-tion, and the differences of EOS, IL-4 and IL-5 were higher than those in the control group (P<0.05). There were no significant differences in VAS, Lund-Kennedy and Lund-Mackay scores and their differences before and six months after surgery between the two groups (P>0.05). The levels of NCV and NMCA and the difference of airway resistance between NCV and NMCA in observation group were higher than those in control group six months after operation, and the airway resistance was lower than that in control group (P<0.05). There were no aggravation cases in both groups, and the proportion of patients with improved olfactory function in the observation group was higher than that in the control group six months after operation (P<0.05). There was no significant difference in the total incidence of complications (13.73% vs 17.65%) and postop-erative recurrence rate (23.53% vs 19.61%) between the two groups (P>0.05). Conclusion The retention of EESS in the middle turbinate facilitates the recovery of nasal function and olfactory function in patients with type 2 inflammatory CRS by reducing inflammatory stress response without increasing the risk of recurrence. |
