| Objective To analyze and compare the clinical characteristics of patients with non-ketotic hyperglycemic hemichorea（HC-NH） and hemichorea-hemiballism caused by acute ischemic stroke（AIS-induced HC-HB）, so as to improve clinicians' understanding of hemichorea-hemiballism. Methods The clinical data of 44 patients with hemichorea-hemiballism treated in the Affiliated Hospital of Neurology Institute of Anhui University of Chinese Medicine, the First Affiliated Hospital of Anhui University of Chinese Medicine, the First Affiliated Hospital of University of Science and Technology of China from July 2018 to April 2024 were retrospectively analyzed. The patients were grouped according to different etiologies. The patients with hemichorea-hemiballism caused by acute ischemic stroke were in the AIS-induced HC-HB group（24 cases）, and the patients with hemichorea-hemiballism caused by non-ketotic hyperglycemia were in the HC-NH group（20 cases）. The two groups of patients were followed up for 3 months after discharge. The laboratory indexes and imaging features at admission, as well as the Fugl-Meyer scores at admission and discharge were compared between the two groups. The clinical efficacy at discharge, 1 month after discharge and three months after discharge was also compared. Results Compared with the AIS-induced HC-HB group, the fasting blood glucose and glycated hemoglobin at admission in the HC-NH group were higher, and the difference was statistically significant（P＜0.05）. In terms of imaging features at admission, patients in the AIS-induced HC-HB group mainly had acute ischemic changes in the basal ganglia region, with common low-density lesions on CT and low-signal lesions on T1WI. Patients in the HC-NH group often had high-density lesions on CT and high-signal lesions on T1WI in the basal ganglia region. The Fugl-Meyer scores of the two groups of patients at discharge were significantly higher than those at admission（P＜0.05）. When comparing between groups, there were statistically significant differences in the FuglMeyer scores at discharge（P＜0.05）. In the comparison of the therapeutic effects at discharge, 1 month after discharge and 3 months after discharge, the differences between the two groups were all statistically significant（P＜0.05）. Conclusion There are differences in laboratory indexes and imaging features between HC-HB caused by AIS and HC-NH. The clinical efficacy and prognosis of HC-NH are better than those of HC-HB caused by AIS. |
