| Objective This research intends to investigate the correlation between bone mineral density（BMD） and the severity of fattyliver disease（FLD） among individuals aged 40 to 60 on health examination data. Methods We selected individuals aged 40-60 who under-went health examinations at the Health Management Center of the First Affiliated Hospital of University of Science and Technology of China, from 2021 to 2023. Based on FibroTouch diagnostic outcomes, they were categorized into three groups: non-FLD（682 cases）, mild FLD（1025cases）, and moderate FLD（681 cases）. An interaction model was constructed to evaluate the interaction between gender, age, and BMD and itscorrelation with different FLD groups. Then, the data was stratified by gender and age, univariate analysis was used to compare the differencesin BMD among different groups, and a multivariate logistic regression model was constructed to explore the association between different FLDgroups and BMD. Results There were statistically significant differences in T-scores, bone mineral content, and BMD among different FLDgroups（P＜0.05）. In females, statistically significant differences were observed in T-scores and BMD among the three groups（P＜0.05）. Logisticregression showed that an increased BMD was a protective factor against the occurrence of mild FLD（OR=0.269, 95%CI: 0.091~0.791）. How-ever, this association was not found in males（P＞0.05）. In the 40~50 age group, statistically significant differences were observed in T-scoresand bone mineral content among the three groups（P＜0.05）, but no significant association was found between BMD and FLD（P＞0.05）.In the 50~60 age group, statistically significant differences were observed in T-scores, bone mineral content, and BMD among the three groups（P＜0.05）. Logistic regression shows that an increased BMD is a protective factor against the occurrence of mild FLD（OR=0.353, 95%CI: 0.126~0.987）. Conclusion In female and aged 50 to 60 populations, significant differences in BMD exist among people with different degrees ofFLD, and a reduced BMD may be associated with the occurrence of mild FLD. |
