Objective To investigate the differences in the clinical efficacy of conventional copper displacement therapy with DMPS and DMPS combined with MPS in the treatment of patients with cerebral Wilson’s disease with magnetic resonance DWI hyperintensity. Methods A total of 70 patients with cerebral Wilson’s disease with magnetic resonance DWI hyperintensity who were hospitalized in the Affiliated Hospital of the Institute of Neurology of Anhui University of Traditional Chinese Medicine from January 2023 to December 2024 were collected, of which 40 patients(control group) were treated with conventional copper removal with DMPS. The other 30 patients(observation group) were treated with MPS in the first course on the basis of conventional copper displacement therapy, and the other treatments were the same as those in the control group. Each copper displacement treatment lasted for 8 days, a total of 8 courses. The differences in UWDRS-Ⅰ and UWDRS-Ⅲ. scores, 24-hour urine copper, homocysteine, blood routine, liver and kidney function and other clinical indicators between the two groups before and after treatment were compared. Results There were no significant differences in UWDRS-Ⅰ score, UWDRS-Ⅲ score, 24-hour urine copper, blood routine, homocysteine, liver and kidney function, and brain magnetic resonance DWI hyperintensity between the two groups before treatment(P>0.05). Compared with before treatment, the UWDRS-Ⅰ, UWDRS-Ⅲ. scores and homocysteine indexes in the two groups were significantly improved after treatment, and the 24-hour urine copper significantly increased(P<0.05), and the total bilirubin and albumin indexes in the observation group were significantly improved(P<0.05). Compared with the control group after treatment, the UWDRS-I and UWDRS-Ⅲ scores and albumin indexes in the observation group were significantly improved after treatment, and the 24-hour urine copper increased significantly(P<0.05). Conclusion The use of DMPS copper displacement combined with MPS in the treatment of patients with DWI hyperintense cerebral WD has better efficacy, since it can improve the neuropsychiatric symptoms and some clinical test indicators. |