| Objective To investigate whether the results of SII/ALB（systemic Immune-Inflammation Index/Albumin, SII/ALB） combined with CRP（C-reactive protein） can evaluate the severity of acute pancreatitis. Methods The clinical data of 214 patients with AP were analyzed retrospectively, and the patients were divided into the mild acute pancreatitis（MAP）, moderately severe acute pancreatitis（MSAP）, and severe acute pancreatitis（SAP） groups. The basic clinical and laboratory data, SII/ALB, SII, APACHE Ⅱ score of the three groups were compared. The receiver operating characteristic（ROC） curves were employed to analyze the value of SII/ALB, SII, CRP, APACHE Ⅱ score, SII/ALB combined CRP for the severity of AP. Results Compared with the MAP group, WBC, amylase, CRP, D-D, NLR, SII/ALB, APACHE Ⅱscore were significantly higher in the MSAP and SAP groups（P＜0.05）; while blood calcium, platelet count, albumin were significantly lower（P＜0.05）. Compared with the MSAP group, the SAP group had significant higher creatinine, BUN, CRP, D-D, SII/ALB, APACHEII score（P＜0.05）; while lymphocyte count and prealbumin were significantly lower in the SAP group（P＜0.05）. ROC curves were generated to evaluate the predictive value of these factors, and the area under the curve for the SII, SII/ALB, CRP, NLR, PLR, APACHE II score, SII/ALB combined CRP was 0.656（sensitivity 0.604; specificity 0.654; cut-off 1 774.38×109/L）, 0.729（sensitivity 0.623; specificity 0.788; cut-off 48.39）, 0.761（sensitivity 0.755; specificity 0.731; cut-off 81.43 mg/L）, 0.730（sensitivity 0.724; specificity 0.615; cut-off 0.69）, 0.593（sensitivity 0.485; specificity 0.754; cut-off 0.71）, 0.842（sensitivity 0.708; specificity 0.846; cut-off 5.50） and 0.814（sensitivity 0.858;specificity 0.712;cut-off 0.53）（P＜0.001）, respectively. Conclusion SII/ALB combined CRP have high efficacy in predicting the severity of AP. It is of clinical value to detect the disease early and to improve the outcomes. |
