| Objective To investigate the levels and diagnostic value of serum glucose regulatory protein 78（GRP78）, fibroblast growth factor 23（FGF23）, and anti-Mullerian hormone（AMH） in patients with PCOS. Methods Two hundreds patients with polycystic ovary syndrome（PCOS） who visited Shangluo City Center Hospital from March 2021 to March 2023 were regarded as experimental group, and 200 normal female volunteers were as reference group. Serum GRP78 and FGF23 levels were detected by enzyme-linked immunosorbent assay and serum AMH levels were detected by chemiluminescence assay; the relevant factors affecting the occurrence of PCOS were analyzed using multivariate logistic regression; the diagnostic value of serum GRP78, FGF23, and AMH levels for PCOS was assessed using receiver operating characteristic（ROC）. curves. Results The body mass index（BMI）, fasting blood glucose（FPG）, fasting insulin（FINS）, insulin resistance index（HOMA-IR）, luteinizing hormone（LH）, and follicle stimulating hormone（FSH） of experimental group were higher than those of reference group（P＜0.05）; the serum levels of GRP78, FGF23, and AMH in experimental group were obviously higher than those in reference group（P＜0.05）; serum high GRP78, high FGF23, high AMH, high BMI, high HOMA-IR, high LH level were the risk factors for PCOS, low FSH level were the protective factors for PCOS（P＜0.05）; the area under the curve（AUC） of the combined diagnosis of serum GRP78, FGF23, and AMH for PCOS was 0.841, which was higher than their respective single diagnoses(Ztriple combined diagnosis-GRP78=4.452, Ztriple combined diagnosis-FGF23=3.356, Ztriple combined diagnosis-AMH=2.262, all P＜0.05), and the sensitivity and specificity of the combined diagnosis was 84.00% and 67.50%, respectively. Conclusion Serum levels of GRP78, FGF23, and AMH are obviously elevated in patients with PCOS, and their combined detection has high diagnostic value for PCOS. |
