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| AECOPD患者出院后维持治疗方案与短期死亡的相关性 |
| Association between maintenance regimen and short-term mortality in patients with AECOPD after discharge |
| 投稿时间：2022-05-10 |
| DOI：10.3969/j.issn.1000-0399.2023.02.003 |
| 中文关键词: 慢性阻塞性肺疾病急性加重 维持治疗方案 死亡率 治疗方案 |
| 英文关键词: Acute exacerbation of chronic obstructive pulmonary disease Maintenance treatment after discharge Mortality Therapeutic regimen |
| 基金项目:陕西省重点研发计划项目(编号:2018SF-012) |
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| 中文摘要: |
| 目的 评估慢性阻塞性肺病急性加重(AECOPD)患者出院后维持治疗方案对出院后90天死亡率的影响。方法 回顾性分析2018年2月至2021年6月陕西省人民医院收治的443例AECOPD患者的临床资料,统计随访患者出院后90天生存结局,使用多因素logistic回归分析出院后维持治疗方案对患者出院后90天内死亡的影响。结果 443例出院患者中,55.8%的患者在出院后接受3联药物治疗,22.1%的患者接受2联药物治疗,18.5%的患者接受单一药物治疗,3.6%的患者接受其他治疗或不接受治疗。443例患者中,33例(7.4%)患者出院后90天内死亡。多因素logistic回归分析显示,在调整了协变量后,出院后维持治疗方案为单一药物[OR(95% CI):7.233(2.443-21.376)]是患者出院90天内死亡的独立危险因素。结论 AECOPD患者出院后维持治疗方案具有多样性特点,出院后单一药物治疗方案较3种药物联合治疗方案具有更高的死亡率。 |
| 英文摘要: |
| Objective To evaluate the effect of post-discharge maintenance regimen on 90-day mortality in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods The clinical data of 443 patients with AECOPD in Shaanxi Provincial People’s Hospital from February 2018 to June 2021 were retrospectively analyzed. Patients were followed up to 90 days after discharge. Multivariate logistic regression was used to analyze the effect of post-discharge maintenance on death within 90 days after discharge. Results Among 443 discharged patients, 55.8% received 3-drug therapy after discharge, 22.1% received 2-drug therapy, 18.5% received single-drug therapy, and 3.6% received other therapy or no therapy. Of the 443 patients, 33(7.4%) died within 90 days of discharge. Multivariate logistic regression analysis showed that, after adjusting for covariates, post-discharge maintenance regimen of single drug [OR (95%CI):7.233(2.443-21.376)] was an independent risk factor for death within 90 days of discharge. Conclusions The post-discharge maintenance regimen of AECOPD patients is characterized by diversity, and the single-drug regimen is associated with a higher mortality rate than the three-drug regimen. |
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