文章摘要
双相情感障碍患者血清中galectin-3的表达水平及其临床意义
Expression level and clinical significance of galectin-3 in serum of patients with bipolar disorder
投稿时间:2023-05-09  
DOI:10.3969/j.issn.1000-0399.2024.01.012
中文关键词: 双相情感障碍  半乳糖凝集素-3  诊断价值
英文关键词: Bipolar affective disorder  Galectin-3  Diagnostic value
基金项目:自贡市精神卫生中心2022年第一批医院科研立项课题(编号:2022ZC09)
作者单位
童颜 643020 四川自贡 自贡市精神卫生中心精神科 
龙赟 643020 四川自贡 自贡市精神卫生中心精神科 
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中文摘要:
      目的 探讨半乳糖凝集素-3(galectin-3)在双相情感障碍患者血清中的表达水平及其临床意义。方法 选取2021年1月至2022年7月在自贡市精神卫生中心接受治疗的102例双相情感障碍患者作为观察组,利用临床总体印象量表严重程度项目(CGI-S)评分,将其分为轻度双相情感障碍患者组40例、中度双相情感障碍患者组34例和重度双相情感障碍患者组28例。根据患者发作状态分为抑郁发作组46例、躁狂发作组35例和混合发作组21例。选择同期105例健康体检志愿者作为对照组。采用酶联免疫吸附(ELISA)法检测受试者血清galectin-3水平;Spearman法分析患者血清galectin-3水平与CGI-S评分的相关性;对影响双相情感障碍发生的因素进行多因素logistic回归分析;受试者工作特征(ROC)曲线分析血清galectin-3水平对双相情感障碍的诊断价值。结果 与对照组相比,观察组血清中galectin-3水平升高(P<0.05);重度双相情感障碍患者组患者血清galectin-3水高于中度和轻度双相情感障碍患者组,中度双相情感障碍患者组血清galectin-3水平高于轻度双相情感障碍患者组,差异均有统计学意义(P<0.05);混合发作组患者galectin-3水平高于躁狂发作组和抑郁发作组,差异有统计学意义(P<0.05);双相情感障碍患者血清galectin-3水平与CGI-S评分呈正相关(r=0.435,P<0.001);galectin-3是影响双相情感障碍发生的危险因素(P<0.05);血清galectin-3水平诊断双相情感障碍的ROC曲线下面积为0.916。结论 双相情感障碍患者血清galectin-3水平升高,且与疾病严重程度有关,可较好地诊断双相情感障碍。
英文摘要:
      Objective To investigate the expression level and clinical significance of galectin-3 in serum of patients with bipolar disorder.Methods A total of 102 patients with bipolar disorder treated in Zigong Mental Health Center from January 2021 to July 2022 were selected as the observation group, then with the use of the clinical global impression scale(CGI-S) scores, they were divided into mild bipolar disorder group of 40 patients, moderate bipolar disorder group of 34 patients, and severe bipolar disorder group of 28 patients.The patients were categorized according to their seizure status into a depressive seizure group of 46 cases, a manic seizure group of 35 cases and a mixed seizure group of 21 cases.Another 105 healthy check-up volunteers in the same period were used as the control group.Enzyme-linked immunosorbent assay(ELISA) was used to detect the level of serum galectin-3 in subjects. Spearman method was applied to analyze the correlation between serum galectin-3 level and CGI-S scores in patients.Multifactor logistic regression analysis was conducted on the factors influencing the occurrence of bipolar disorder.ROC curve was employed to analyze the diagnostic value of serum galectin-3 level in patients.Results Compared with the control group, the serum galectin-3 level in the observation group was obviously higher(P<0.05). Serum galectin-3 levels of patients in the severe bipolar disorder patient group were higher than those in the moderate bipolar disorder patient group and the mild bipolar disorder patient group, serum galectin-3 levels of patients in the moderate bipolar disorder patient group were higher than those in the mild bipolar disorder patient group, and the difference was statistically significant(P<0.05).Patients in the mixed episode group had significantly higher galectin-3 levels than those in the manic and depressive episode groups, and the difference was statistically significant(P<0.05), serum galectin-3 level in patients with bipolar disorder was positively correlated with CGI-S score(r=0.435, P<0.001).Galectin-3 was a risk factor for bipolar disorder(P<0.05), the area under the ROC curve(AUC) of serum galectin-3 level in the diagnosis of bipolar affective disorder was 0.916.Conclusion The serum galectin-3 level in patients with bipolar affective disorder is elevated, which is related to the severity of the disease, and can better diagnose bipolar disorder.
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