文章摘要
Wilson病患者合并脑白质病变临床相关的危险因素探讨
An examination of clinically relevant risk factors in patients with Wilson’s disease combined with white matter lesions
投稿时间:2023-08-12  
DOI:10.3969/j.issn.1000-0399.2024.04.002
中文关键词: Wilson病  脑白质病变  同型半胱氨酸  尿铜  铜蓝蛋白  血糖  血脂
英文关键词: Wilson's disease  White matter lesions  Homocysteine  Urine copper  Copper blue protein  Blood glucose  Blood lipids
基金项目:国家自然科学基金面上项目(编号:81473535); 安徽中医药大学自然科学研究重大项目(编号:2021sfylco1)
作者单位E-mail
王爱玲 230012 安徽合肥 安徽中医药大学研究生院
230061 安徽合肥 安徽中医药大学神经病研究所附属医院 
 
胡文彬 230012 安徽合肥 安徽中医药大学研究生院 hwbzhx@163.com 
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中文摘要:
      目的 探讨Wilson病(WD)患者合并脑白质病变(WMLs)临床相关的危险因素。方法 招募2022年8月至2023年6月期间在安徽中医药大学神经病研究所附属医院住院的43例WD合并WMLs患者作为研究组,以同时期住院的44例无WMLs的WD患者作为对照组,进行回顾性研究。比较两组患者一般资料、治疗前24 h尿铜、血清铜蓝蛋白、血清铁、血糖、血脂与同型半胱氨酸、尿酸、肌酐等临床检验指标间的差异,用二分类logistic回归分析筛选WD合并WMLs相关危险因素,Spearman相关性分析观察治疗前24h尿铜与同型半胱氨酸之间的相关性。结果 研究组患者的同型半胱氨酸、治疗前24 h尿铜高于对照组,差异有统计学意义(P<0.05),而两组患者的血清铜蓝蛋白、血清铁、血糖、血脂与尿酸、肌酐之间的差异无统计学意义(P>0.05)。二分类logistic回归分析显示同型半胱氨酸增高是WD合并WMLs的危险因素(OR=1.105,95%CI:1.013~1.205,P=0.024)。结论 血清同型半胱氨酸增高是WD合并WMLs的危险因素。
英文摘要:
      Objective To investigate the clinically relevant risk factors for Wilson's disease(WD) patients with combined cerebral white matter lesions(WMLs).Methods Forty-three patients with WD combined with WMLs who were hospitalized in the Affiliated Hospital of Neurological Institute of Anhui University of Traditional Chinese Medicine between August 2022 and June 2023 were recruited as the study group, and 44 WD patients without WMLs hospitalized in the same period as the control group, then the clinical data of the two groups were retrospectively analyzed and studied. The differences in the general data of the two groups of patients, 24 h urine copper, serum copper blue protein, serum iron, blood glucose, blood lipids and homocysteine, uric acid, creatinine and other clinical test indexes were compared, the risk factors related to WD combined with WMLs were analyzed with bicategory logistic regression analysis, the correlation between the 24 h urine copper and homocysteine before the treatment was observed with Spearman's correlation analysis.Results The homocysteine and 24 h urine copper before treatment were higher in the study group than in the control group, and the differences were statistically significant(P<0.05),while the differences in serum copper blue protein, serum iron, blood glucose, blood lipids, and uric acid and creatinine were not statistically significant in the two groups(P>0.05). Two-category logistic regression analysis showed that increased homocysteine was a risk factor for WD combined with WMLs(OR=1.105, 95% CI: 1.013~1.205, P=0.024).ConclusionIncreased serum homocysteine is a risk factor for WD combined with WMLs.
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