| Objective To evaluate the risk factors and etiological characteristics of post-neurosurgical bacterial meningitis/ventriculitis (PNBM/BV). Methods According to the selection criteria and the diagnostic criteria of PNBM/BV, 61 post-neurosurgical patients were divided into PNBM/BV group (31 cases) and non-PNBM/BV group (30 cases). The differences of some risk factors，including length of stay, emergency operation, number of operations, antibiotic prophylaxis, duration of the operation, intraoperative blood transfusion, foreign body implantation, indwelling time of drainage tube, postoperative blood glucose control, Glasgow coma score less than or equal to 8, hypoalbuminemia, microbiological spectrum and clinical outcome, were compared between two groups. Results Compared with the non-PNBM/BV group, the risk factors，including average stay, emergency operation, extended operation duration beyond 4 hours, secondary operation, intraoperative blood transfusion, foreign body implantation, extended drainage tube beyond 4 days, diabetes mellitus or poor blood glucose control, Glasgow coma score less than or equal to 8 and hypoproteinemia, were higher than the PNBM/BV group (p < 0.05). There was no significant difference in antibiotic prophylaxis, intraoperative blood transfusion and anemia between two groups (p > 0.05). Non-conditional Logistic regression analysis showed that diabetes mellitus or poor postoperative blood glucose control, hypoalbuminemia and foreign body implantation were independent risk factors for PNBM/BV. In PNBM/BV group, 10 cases were positive for cerebrospinal fluid bacterial culture. 7 cases were Gram-negative bacteria and all of them were widely drug-resistant (PDR) bacterial strains, the fatality rate was 25.8%. Conclusion The risk factors should be corrected as soon as possible after neurosurgery, which is helpful to improve the clinical outcome. |
