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| DWI在前列腺癌诊断中的价值及ADC值与临床分期血清PSA的相关性 |
| The diagnostic value of DWI in prostate cancer and correlation between ADC-value clinical stage and PSA |
| 投稿时间：2014-12-25 修订日期：2015-02-17 |
| DOI：10.3969/j.issn.1000-0399.2015.06.003 |
| 中文关键词: 弥散加权成像 表观弥散系数 前列腺特异性抗原 前列腺癌 |
| 英文关键词: Diffusion weighted imaging Apparent diffusion coefficient Prostate specific antigen Prostate cancer |
| 基金项目:安徽省卫生和计划生育委员会中医药科研课题基金(项目编号:2014zy30) |
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| 中文摘要: |
| 目的 探讨3.0T磁共振弥散加权成像(DWI)在前列腺癌(PCa)诊断中的价值, 并分析感兴趣区表观弥散系数值(ADC)与临床分期、血清前列腺特异性抗原(PSA)的相关性。方法 分析经穿刺活检或手术病理确诊的47例PCa患者, 所有患者均行常规MRI扫描及DWI检查, 在常规MRI图像上观察前列腺病灶的位置、大小、信号及累计范围, 观察病灶区DWI信号并测量ADC值。结果 47例PCa患者中, 29例位于外周带, 14例位于中央带, 4例同时累及中央带和外周带, 所有病例DWI上均表现为高信号或稍高信号, 在相应ADC图上表现为低信号或稍低信号;PCa病灶平均ADC值约为(0.97±0.33)×10-3 mm2/s, 与临床分期及血清PSA呈负相关(r值分别为-0.54, -0.66, P<0.05)。结论 MRI常规序列联合DWI检查及血清PSA检测可以提高PCa的诊断, 测量病灶的ADC值有助于对PCa的临床分期进行初步评估, 进而指导临床选择合适的治疗方案。 |
| 英文摘要: |
| Objective To evaluate the diagnostic value of 3.0T diffusion weighted imaging(DWI) in prostate cancer and to analyse the correlation between ADC-value, clinical stage and PSA. Methods The clinical data of 47 cases diagnosed as prostate cancer after biopsy or operation pathologically were analysed; all patients underwent routine MRI scanning and DWI examination, on MRI routine scan the lesions of the prostate position, size, signal and accumulated in the range were observed, then the focus DWI signal was observed and ADC-value was determined. Results Among 47 cases of prostate cancer, 29 were located in the peripheral zone, 14 in the central zone, and 4 in the central and peripheral zone; all of the cases' DWI show high signal or slightly high signal, and on corresponding area ADC showed low signal or slightly low signal; the average ADC-value was (0.97±0.05)×10-3mm2/s. Negative correlation was found with clinical stage and PSA(r=-0.54, -0.66, P<0.05). Conclusion MRI routine scan and DWI examination and PSA test can improve the diagnosis of prostate cancer, and measuring focus ADC-value can be helpful to estimate the clinical stage, and further guide the clinicians to select appropriate treatment options. |
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