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| 孕酮CA125及β-HCG在宫外孕诊断中的价值 |
| Diagnosticvalue of progesterone, CA125 and β-HCG in ectopic pregnancy |
| 投稿时间：2015-04-25 修订日期：2015-07-02 |
| DOI：10.3969/j.issn.1000-0399.2015.08.005 |
| 中文关键词: 宫外孕 孕酮 CA125 β-HCG |
| 英文关键词: Ectopic pregnancy Progesterone CA125 β-HCG |
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| 中文摘要: |
| 目的 探讨孕妇血清孕酮、CA125及β-HCG水平单独及联合检测在宫外孕诊断中的价值。 方法 选择2013年6月至2014年10月安徽省第二人民医院妇产科收治入院的宫外孕患者和同期就诊的正常早孕女性作为研究对象,其中宫外孕组39例,正常早孕组30例,所有患者均行血清孕酮、CA125含量检测及β-HCG 48 h增长率计算。比较分析以上3个指标在两组受检者中的差异,并通过回顾性分析,研究影响孕酮、CA125水平和β-HCG 48 h增长率检测的因素及对3项指标联合检测在宫外孕诊断中的特异性、灵敏性进行分析比较。 结果 ① 宫外孕组患者血清孕酮、CA125水平及β-HCG 48 h增长率检测结果分别是:(9.28±3.34) ng/mL, (19.74±14.17) U/mL, (22.25±13.63) %,而在正常早孕组分别是:(25.90±11.94) ng/mL, (72.36±25.99) U/mL, (101.85±27.49) %。宫外孕受检者血清孕酮、CA125水平及β-HCG 48 h增长率均较正常早孕者低,差异有统计学意义(P <0.05)。ROC分析提示3项指标均可应用于宫外孕的诊断,其中以β-HCG 48 h增长率测定诊断价值最高。②回顾性研究发现,血清孕酮、CA125水平、β-HCG 48 h增长率及3项指标联合检测宫外孕诊断灵敏度分别为:71.8%,74.4%,87.2%,98.5%;特异度分别为:70%,96.7%,86.7%,90.5%。 结论 无论是血清孕酮、CA125水平及β-HCG 48 h增长率各单项指标检测还是联合测定,对宫外孕均有重要辅助诊断价值,但联合检测的诊断价值要优于任一单项血清指标。 |
| 英文摘要: |
| Objective To investigate the diagnosticvalue of singleor combined measurement of serum progesterone, CA125 and β-HCG levelsin ectopic pregnancy.Methods 39 cases of exfetation patients hospitalized in our departmentfrom Oct 2013 to Jun 2014and 30 cases ofearly pregnancy outpatientswere enrolledas subjects. The serum progesteroneand CA125 levels and the growth rate of β-HCG within 48 hours were measured in all the patients,andthe differences of these three indexes between the two groupswere compared for significance. The affected factors and the specificity and sensitivity of combined measurement of these threeindexes in the diagnosis of ectopic pregnancy were investigated by a retrospective study. Results The respective mean values of serum progesterone and CA125 levelsand growthrate ofβ-HCGwithin 48hoursin the ectopic pregnancy group were (9.28±3.34)ng/mL, (19.74±14.17)U/mL and (22.25±13.63)%, whereas the mean values of theindexes above in the early pregnancy group were (25.90±11.94)ng/mL, (72.36±25.99)U/mL and (101.85±27.49)%, respectively. The values of these threeindexesin the ectopic pregnancy group were much lower than those in the early pregnancy group,and the differencesbetween themwere statistically significant (P <0.05). Results of ROC analysis indicated that, all the three indexes can be applied to diagnosis ectopic pregnancy, but the diagnostic value of growthrate ofβ-HCGwithin 48hours was highest. As aretrospective study showed, the respectivesensitivity of singleor combined measurement of serum progesterone, CA125 and β-HCG levels were 71.8%,74.4%, 87.2% and 98.5%,and the specificity of singleor combined measurementwere 70%, 96.7%, 86.7%and 90.5%, respectively. Conclusion Both the singleindexofserum progesterone and CA125 levelsand growthrate ofβ-HCGwithin 48hours and the combined measurement of these indexeshave predictive value for exfetation, but the latter is more accurateandeffective than any of the single index. |
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