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| 血清总胆汁酸在早产儿胃肠外营养相关性胆汁淤积中的诊断意义 |
| Diagnostic significance of serum total bile acids in preterm infants with parenteral nutrition associated cholestasis |
| 投稿时间：2015-04-18 修订日期：2015-06-11 |
| DOI：10.3969/j.issn.1000-0399.2015.08.011 |
| 中文关键词: 总胆汁酸 胃肠外营养 胆汁淤积 早产儿 诊断 |
| 英文关键词: Total bile acids Parenteral nutrition Cholestasis Preterm infant Diagnosis |
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| 摘要点击次数: 1956 |
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| 中文摘要: |
| 目的 探讨血清总胆汁酸(TBA)在早产儿胃肠外营养相关性胆汁淤积诊断中的意义。方法 选取2013年1月至2013年12月应用胃肠外营养(PN)支持治疗14 d以上的早产儿65例,按照是否合并胃肠外营养相关性胆汁淤积(PNAC)分为对照组(53例)及观察组(12例),对比观察两组早产儿谷丙转氨酶(ALT)、谷草转氨酶( AST)、碱性磷酸酶(ALP)、谷氨酰转肽酶(GGT)、TBA、血清总胆红素(TBil)以及直接胆红素(DBil)之间的差异。结果 观察组早产儿血中ALT、AST、ALP、TBA及DBil均高于对照组,差异有统计学意义(P <0.05)。TBA的灵敏度和特异度均高于ALT、AST、ALP、GGT、TBil,差异有统计学意义(P <0.05),且当血清TBA为36 μmol/L时,其血清诊断灵敏度、特异度分别为83.3%、96.2%,此时TBA的准确度最高。结论 监测血清TBA可作为早产儿PNAC的早期诊断指标。 |
| 英文摘要: |
| Objective To investigate the diagnostic significance of serum total bile acids(TBA)inpreterm infants withparenteral nutrition associated cholestasis. Methods 65 cases ofpreterm infantsever treated with parenteral nutrition for more than14 days in our hospital from Jan 2013 to Dec 2013 were enrolledand divided into the study group, which with parenteral nutrition associated cholestasis(PNAC), and the control group, which without PNAC. The serumlevels of ALT, AST, ALP, GGT, TBA,TBiland DBil were analyzedand compared between the two groups. Results In the study group, serum ALT, AST, ALP, TBA and DBillevels were significantly higher than those in the control group (P <0.05). The sensitivity and specificity of serumTBA were significantly higher than that ofALT, AST, ALP, GGTand TBil (P <0.05),and the respectivesensitivity and specificity of serumTBA were 83.3% and 96.2% with highest accuracywhen theserum TBAreached36 μmol/L. Conclusion Monitoring the serum TBA is helpfulto early diagnosis ofPNAC inpreterm infants, and has an important clinical significance. |
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