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| 乙型肝炎表面抗原定量与原发性肝癌的相关性研究 |
| Association between hepatitis B virus surface antigen quantification and HBV-related hepatocellular carcinoma |
| 投稿时间：2014-12-31 修订日期：2015-07-02 |
| DOI：10.3969/j.issn.1000-0399.2015.09.003 |
| 中文关键词: 乙型肝炎表面抗原 慢性乙型肝炎 原发性肝癌 HBV-DNA载量 |
| 英文关键词: Hepatitis B surface antigen Chronic Hepatitis B Hepatocelluar carcinoma Hepatitis B viral load |
| 基金项目:国家自然科学基金项目(项目编号:81273142);安徽省卫生厅科研基金(项目编号:2010C053) |
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| 中文摘要: |
| 目的 比较慢性乙型肝炎(CHB)与HBV相关性原发性肝癌患者中乙肝表面抗原(HBsAg)和HBV DNA 载量情况。方法 采用化学发光法检测403例CHB及肝细胞肝癌(HCC)患者血清乙型肝炎病毒标志物滴度,采用荧光定量PCR技术检测患者血清HBV DNA载量。403例患者按照临床诊断分为CHB组(209例)和HCC组(194例)。结果 CHB组:血清HBsAg 滴度≥250 IU/mL 者占89.00%; HBV DNA≥1 000 copies /mL 者占88.40%。HCC 组: 血清HBsAg 滴度≥250 IU/mL 者占79.90%; HBV DNA≥1 000 copies /mL 者占67.70%。两组HBsAg≥250 IU/mL患者的比例差异、HBV DNA≥1 000 copies/mL 患者的比例差异均有统计学意义(P<0.05)。结论 与CHB相比,HBV相关性原发性肝癌患者HBsAg、HBV DNA载量较低。 |
| 英文摘要: |
| Objective To compare the HBsAg and HBV DNA load between chronic Hepatitis B (CHB) and HBV-related hepatocellular carcinoma (HCC) patients. Methods A total of 403 patients with chronic Hepatitis B (CHB) and HCC were enrolled. HBV serological markers were tested by chemoluminescence method, and serum HBV-DNA level was detected by fluorescent quantitation PCR technology. All patients were divided into CHB group(209 patients)and HCC group(194 patients)according to clinical diagnosis. Results In CHB group, 89.00% patients had serum HBsAg titers≥250 IU/mL and 88.40% patients had HBV DNA≥1 000 copies/mL. In the meantime,79.90% and 67.70% patients with HCC had serum HBsAg titers≥250 IU/mL and HBV DNA≥1 000 copies/mL, respectively. The differences in HBsAg≥250 IU/mL, HBV DNA≥1 000 copies/mL between the two groups was significant (P<0.05). Conclusion Compared with chronic hepatitis B, the patients of HBV-related hepatocellular carcinoma has lower HBsAg and HBV DNA load. |
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