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| 血清降钙素原测定在儿童全身炎症反应综合征的临床应用价值 |
| Clinical value of procalcitonin in treatment of systematic inflammatory response syndrome among children |
| 投稿时间：2015-04-30 修订日期：2015-07-02 |
| DOI：10.3969/j.issn.1000-0399.2015.09.014 |
| 中文关键词: 降钙素原 全身炎症反应综合征 抗菌药物 |
| 英文关键词: Procalcitonin Systematic inflammatory response syndrome Antibiotics |
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| 中文摘要: |
| 目的 分析降钙素原(PCT)在儿童全身炎症反应综合征诊疗中的临床价值,探讨PCT在儿童全身炎症反应治疗中的指导作用。方法 177例全身炎症反应综合征患儿随机分为常规组(89例)和 PCT组(88例)。常规组参照国家治疗指南标准使用抗菌药物治疗;PCT组按照PCT水平决定是否使用抗菌药物,血清PCT≥0.50 ng/mL,使用抗菌药物治疗;PCT<0.50 ng/mL不使用抗菌药物。比较两组患儿的炎症标志物水平、抗菌药物使用时间及住院时间。结果 PCT组治疗前后的炎症指标与常规组差异无统计学意义(P>0.05);但PCT组的抗菌药物使用率、使用时间及住院时间明显短于常规组,差异有统计学意义(P<0.05)。结论 动态监测患儿PCT水平,对于减少抗菌药物使用及缩短住院时间具有重要的临床指导意义。 |
| 英文摘要: |
| Objective To assess the clinical value of procalcitonin (PCT) in the treatment of systematic inflammatory response syndrome (SIRS) among children. Methods A total of 177 children with SIRS in our ward were divided into routine group and PCT-guided treatment group (PCT group) randomly. The children in routine group were treated with antibiotics according to the guideline for antibiotics use. Meanwhile, whether to use antibiotics of the children in PCT group was decided by serum level of PCT. Antibiotics were used when PCT level was more than 0.50 ng/mL and antibiotics were not used when PCT level was less than 0.50 ng/mL. Inflammatory markers, time of antibiotics use and inpatient days were compared between the two groups. Results There was no significant difference in white blood cell, C reaction protein(CRP) and clinical effects of patients in PCT group after antibiotics use between PCT group and routine group(P>0.05). However, days of antibiotics use and inpatient stay in PCT group were significant shorter than in routine group(P<0.05). Conclusion Monitoring serum lever of PCT is of important clinical significance in reducing the use of antibiotics and shortening the course of treatment. |
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