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| 直肠癌患者癌组织中维生素D受体和NF-κB p65的表达及其意义 |
| Expression of vitamin D receptor and NF-κB p65 in rectal cancer and its clinical significance |
| 投稿时间：2015-04-05 修订日期：2015-04-05 |
| DOI：10.3969/j.issn.1000-0399.2015.010.001 |
| 中文关键词: 直肠癌 维生素D受体 核转录因子-κB |
| 英文关键词: Rectal cancer Vitamin D receptor NF-κB |
| 基金项目:国家自然科学基金项目编号(81402676) |
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| 摘要点击次数: 1672 |
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| 中文摘要: |
| 目的 研究维生素D受体(VDR)和核转录因子(NF)-κB p65在直肠癌患者癌组织中的表达水平。方法 选取直肠癌患者和正常直肠黏膜各32例为研究对象,采用免疫组织化学技术检测直肠癌和对照标本VDR和NF-κB p65 表达水平。结果 直肠癌组织有2例VDR表达阳性(6.25%,2/32),有6例NF-κB p65表达阳性(18.75%,6/32);而对照组有28例VDR表达阳性(87.50%, 28/32),29例NF-κB p65(90.62%, 29/32)表达阳性。直肠癌组织VDR和NF-κB p65阳性表达均低于对照组(P < 0.05)。结论 在人直肠癌组织中VDR和NF-κB p65呈低表达。 |
| 英文摘要: |
| Objective To determine the expression of vitamin D receptor (VDR) and nuclear factor (NF)-κB in human rectal cancer and explore the clinical significance of VDR. Methods The specimens of 32 cases of surgically resected tissue and 32 people of control were collected for detecting the expression of VDR and NF-κB p65 by immunohistochemistry. Results In the specimens of 27 cases, the VDR expression of 2 cases(6.25%, 2/32) and NF-κB p65 of 6 cases(18.75%, 6/32) was positive, but VDR expression of 28 cases(87.50%, 28/32) and NF-κB p65 of 29 cases(90.62%, 29/32) was positive in the specimens of 32 control. Compared with control, the expressions of VDR and NF-κB p65 were lower in 32 cases, and the difference between two groups had statistical significance. Conclusion The lower expression of VDR and NF-κB p65 is in human rectal cancer. |
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