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| 氟西汀联合抗精神病药物治疗伴有强迫症状的精神分裂症患者的效果 |
| Effect of fluoxetine combined antipsychotic drug treatment on obsessive-compulsion symptoms of schizophrenia patients |
| 投稿时间：2015-03-30 修订日期：2015-06-01 |
| DOI：10.3969/j.issn.1000-0399.2015.010.010 |
| 中文关键词: 精神分裂症 强迫症状 氟西汀 抗精神病药物 生活质量 |
| 英文关键词: Schizophrenia Forced symptoms Fluoxetine Antipsychotic drugs Quality of life |
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| 中文摘要: |
| 目的 探讨氟西汀联合抗精神病药物治疗伴有强迫症状的精神分裂症患者的临床效果。方法 收集2013年1月至2014年12月收治的具有强迫症状的精神分裂症患者80例,根据数字表法将患者分为观察组与对照组,各40例,开展前瞻性研究,对照组给予抗精神病药物治疗,观察组在抗精神病药物治疗的基础上加用氟西汀,治疗4、8周后观察两组患者临床疗效,以及阳性与阴性症状量表(PANSS)、Yale-Brown强迫症状量表(Y-BOCS)和生活质量评分变化,同时记录不良反应的发生情况。结果 观察组的总有效率为90%,显著高于对照组的70%,差异有统计学意义(P<0.05);治疗4、8周后,两组患者的PANSS、Y-BOCS评分均低于治疗前;且观察组的PANSS、Y-BOCS评分均低于对照组,差异均有统计学意义(P均<0.05);观察组治疗后的物质生活、躯体功能、心理功能、社会功能及总分均高于对照组,差异均有统计学意义(P均<0.05)。结论 对有强迫症状的精神分裂症患者采用氟西汀联合抗精神病药物治疗,能有效改善患者的精神症状及强迫症状,有利于提高患者的生活质量。 |
| 英文摘要: |
| Objective To study the clinical effect of fluoxetine combined with antipsychotic drug therapy on forced symptoms of schizophrenia patients. Methods Eighty cases of patients with forced symptoms of schizophrenia from January 2013 to December 2014 were recruited in this study and randomly divided into observation group and control group according to the digital meter method, with 40 cases in each group. For the prospective study, the control group was given conventional antipsychotic drug therapy, while the observation group receive combined fluoxetine treatment on the basis of antipsychotic drug treatment. After eight weeks of treatment, the clinical efficacy of two groups and the positive and negative symptoms scale (PANSS), Yale-Brown obsessional-compulsive inventory (Y BOCS) and quality of life score changes were observed, and at the same time the occurrence of adverse reactions was recorded. Results The total effective rate of observation group(90%) was significantly higher than that of control group(70%), and the difference was statistically significant (P<0.05); 4 weeks, 8 weeks after treatment, positive and negative symptoms scale (PANSS), Yale-Brown obsessional-compulsive inventory (Y BOCS) score of the two groups were significantly lower than those before treatment. And PANSS, Y BOCS score in observation group were significantly lower than those of control group, and the differences were statistically significant (P<0.05). The material life, physical function, psychological function, social function and total score of observation group after treatment were significantly higher than those of the control, and the difference had statistical significance (P<0.05). Conclusion Fluoxetine combined therapy with antipsychotic drugs in treating forced symptoms of schizophrenia patients can effectively improve patients' mental symptoms and obsessive-compulsive symptoms and improve the quality of life of patients; its curative effect is reliable, and thus is worth promoting. |
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