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| 353例小儿肾小球疾病的病理及临床分布特点 |
| Pathologic and clinical characteristics of infantile glomerular diseases in 353 cases |
| 投稿时间：2015-06-09 修订日期：2015-09-14 |
| DOI：10.3969/j.issn.1000-0399.2015.11.003 |
| 中文关键词: 肾活检 肾小球肾炎 病理学 儿童 |
| 英文关键词: Renal Biopsy Glomerular Nephritis Pathology Child |
| 基金项目:安徽省卫生和计划委员会妇儿课题(项目编号:BFR018) |
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| 中文摘要: |
| 目的 了解小儿肾小球疾病病理与临床分布特点。方法 收集353例肾活检患儿资料进行回顾性分析。结果 353例患儿中诊断为紫癜性肾炎117例(33.1%),孤立性血尿94例(26.6%),原发性肾病综合征87例(24.6%),急性肾炎综合征23例(6.5%),其次还有乙肝相关性肾炎、狼疮性肾炎、孤立性蛋白尿、慢性肾炎等。肾小球疾病中以原发性肾小球疾病最为常见(206例,占58.4%),病理改变主要为:系膜增生性肾小球肾炎(MsPGN)66例,占32.0%; IgA肾病(IgA N)54例,占26.2%;轻微病变37例,占18.0%;其他还包括微小病变(MCD)、膜增生性肾小球肾炎(MPGN)、膜性肾病(MN)、毛细血管增生性肾小球肾炎等。继发性肾小球疾病以紫癜性肾炎最常见。结论 肾小球疾病以原发性肾小球疾病为主,临床诊断以孤立性血尿最常见,继发性肾炎以紫癜性肾炎最常见。 |
| 英文摘要: |
| Objective To explore the pathological and clinical features of glomerular diseases in children. Methods The pathological data of 353 children with biopsy-proven glomerular diseases were retrospectively analyzed. Results 353 cases of children were separately diagnosed with Henoch-Schonlein purpura nephritis (117 cases, accounting for 33.1%), isolated hematuria (94 cases, 26.6%), primary nephrotic syndrome (87 cases, 24.6%), acute nephritis syndrome (23 cases, 6.5%), followed by hepatitis B-related nephritis, lupus nephritis, isolated proteinuria, chronic nephritis, etc. The primary glomerular disease was the most common glomerular diseases (206 cases, 58.4%), its pathological changes mainly manifested as mesangial proliferative glomerulonephritis (75 cases, 34.9%), IgA nephropathy (54 cases, 25.1%) and glomerular minor lesion (37 cases, 17.2%), and the others included minimal change disease, membrane proliferative glomerulonephritis, membranous nephropathy, capillaries proliferative glomerulonephritis, etc. The most common secondary glomerular disease was Henoch-Schonlein purpura nephritis. Conclusion Primary glomerular diseases are most common in infantile glomerular diseases, with main clinical diagnosis of isolated hematuria, and the most common secondary glomerulonephritis is Henoch-Schonlein purpura nephritis. |
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